106305
Nitrilotriacetic acid trisodium salt monohydrate
≥99%
Synonym(s):
Sodium nitrilotriacetate tribasic monohydrate
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About This Item
Linear Formula:
N(CH2COONa)3 · H2O
CAS Number:
Molecular Weight:
275.10
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
225-768-6
MDL number:
assay
≥99%
InChI key
HERBOKBJKVUALN-UHFFFAOYSA-K
InChI
1S/C6H9NO6.3Na.H2O/c8-4(9)1-7(2-5(10)11)3-6(12)13;;;;/h1-3H2,(H,8,9)(H,10,11)(H,12,13);;;;1H2/q;3*+1;/p-3
SMILES string
O.[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O
mp
>300 °C (lit.)
Application
Nitrilotriacetic acid trisodium salt monohydrate was used to develop capillary zone electrophoretic method for determination of eight carboxylates as copper complexes.
Biochem/physiol Actions
Nitrilotriacetic acid trisodium salt monohydrate is a potent nongenotoxic carcinogen and has induced tumors of the urinary bladder and kidney on long term administration in rats. It induces diphtheria toxin-resistant mutants in human cell lines. It inhibits gap-junctional communication between chinese hamster lung fibroblast.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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S Inoue et al.
Cancer research, 47(24 Pt 1), 6522-6527 (1987-12-15)
Reactivities of Fe3+ chelates of aminopolycarboxylic acids with DNA were investigated by the DNA-sequencing technique using 32P 5'-end-labeled DNA fragments obtained from the human c-Ha-ras-1 protooncogene, and the reaction mechanism was studied by electron spin resonance spectroscopy. Ferric nitrilotriacetate (Fe3+-NTA)
Pirkko-Leena Laamanen et al.
Journal of chromatography. A, 1095(1-2), 164-171 (2005-11-09)
Two new methods of capillary zone electrophoresis based on aqueous phosphate running buffers with UV spectrophotometric detection were developed and optimized for the determination of eight carboxylates as copper complexes. Metalcomplexes are negatively charged, so measurements were made as anion
A R Malcolm et al.
Cell biology and toxicology, 5(2), 145-153 (1989-06-01)
Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication
M P Grilli et al.
Toxicology letters, 25(2), 137-141 (1985-05-01)
The mutagenic potential of nitrilotriacetic acid trisodium salt monohydrate (NTA) was evaluated on a human cell line (EUE) using selection for diphtheria toxin (DT) resistance. Cultures were treated with different doses of the chemical (2 X 10(-2)-2 X 10(-8) M)
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