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106305

Sigma-Aldrich

Nitrilotriacetic acid trisodium salt monohydrate

≥99%

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Synonym(s):
Sodium nitrilotriacetate tribasic monohydrate
Linear Formula:
N(CH2COONa)3 · H2O
CAS Number:
18662-53-8
Molecular Weight:
275.10
EC Number:
225-768-6
MDL number:
MFCD00150789
UNSPSC Code:
12352100
PubChem Substance ID:
24846729

Assay

≥99%

mp

>300 °C (lit.)

SMILES string

O.[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O

InChI

1S/C6H9NO6.3Na.H2O/c8-4(9)1-7(2-5(10)11)3-6(12)13;;;;/h1-3H2,(H,8,9)(H,10,11)(H,12,13);;;;1H2/q;3*+1;/p-3

InChI key

HERBOKBJKVUALN-UHFFFAOYSA-K

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Application

Nitrilotriacetic acid trisodium salt monohydrate was used to develop capillary zone electrophoretic method for determination of eight carboxylates as copper complexes.

Biochem/physiol Actions

Nitrilotriacetic acid trisodium salt monohydrate is a potent nongenotoxic carcinogen and has induced tumors of the urinary bladder and kidney on long term administration in rats. It induces diphtheria toxin-resistant mutants in human cell lines. It inhibits gap-junctional communication between chinese hamster lung fibroblast.

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Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H319,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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A R Malcolm et al.
Cell biology and toxicology, 5(2), 145-153 (1989-06-01)
Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication
S Inoue et al.
Cancer research, 47(24 Pt 1), 6522-6527 (1987-12-15)
Reactivities of Fe3+ chelates of aminopolycarboxylic acids with DNA were investigated by the DNA-sequencing technique using 32P 5'-end-labeled DNA fragments obtained from the human c-Ha-ras-1 protooncogene, and the reaction mechanism was studied by electron spin resonance spectroscopy. Ferric nitrilotriacetate (Fe3+-NTA)
Pirkko-Leena Laamanen et al.
Journal of chromatography. A, 1095(1-2), 164-171 (2005-11-09)
Two new methods of capillary zone electrophoresis based on aqueous phosphate running buffers with UV spectrophotometric detection were developed and optimized for the determination of eight carboxylates as copper complexes. Metalcomplexes are negatively charged, so measurements were made as anion
M P Grilli et al.
Toxicology letters, 25(2), 137-141 (1985-05-01)
The mutagenic potential of nitrilotriacetic acid trisodium salt monohydrate (NTA) was evaluated on a human cell line (EUE) using selection for diphtheria toxin (DT) resistance. Cultures were treated with different doses of the chemical (2 X 10(-2)-2 X 10(-8) M)

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