104590
N,N′-(o-Phenylene)dimaleimide
99%
Synonym(s):
1,2-Dimaleimidobenzene
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About This Item
Empirical Formula (Hill Notation):
C14H8N2O4
CAS Number:
Molecular Weight:
268.22
UNSPSC Code:
12162002
NACRES:
NA.23
PubChem Substance ID:
EC Number:
236-046-5
Beilstein/REAXYS Number:
249426
MDL number:
InChI key
UFFVWIGGYXLXPC-UHFFFAOYSA-N
InChI
1S/C14H8N2O4/c17-11-5-6-12(18)15(11)9-3-1-2-4-10(9)16-13(19)7-8-14(16)20/h1-8H
SMILES string
O=C1C=CC(=O)N1c2ccccc2N3C(=O)C=CC3=O
assay
99%
mp
245-247 °C (dec.) (lit.)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M Elzinga et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(21), 6599-6602 (1984-11-01)
The bifunctional reagent N,N'-p-phenylenedimaleimide (PDM) is being used in an attempt to measure distances between specific side chains in adjacent monomers within F-actin. [14C]PDM was synthesized and was used to crosslink F-actin. Uncrosslinked actin was removed by gel filtration, and
R T King et al.
The Journal of biological chemistry, 262(13), 6128-6134 (1987-05-05)
Electron microscopy studies have shown that the structure of the complex of myosin subfragment 1 (S-1) cross-linked to actin with 1-ethyl-3-[3-(dimethyl-amino) propyl] carbodiimide is very different in the presence and absence of ATP (Craig, R., Greene, L. E., and Eisenberg
T Katoh et al.
European journal of biochemistry, 227(1-2), 459-465 (1995-01-15)
Porcine aorta myosin was reacted with a bifunctional cross-linking reagent, N,N'-o-phenylenedimaleimide. The 17-kDa essential light chain (LC17) in each myosin head was intramolecularly cross-linked within a single myosin molecule. The 34-kDa cross-linked LC17 dimer was isolated and its peptide map
L E Greene et al.
Biochemistry, 25(3), 704-709 (1986-02-11)
In our previous study [Chalovich, J. M., Greene, L. E., & Eisenberg, E. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 4909-4913], myosin subfragment 1 that was modified by having its two reactive thiol groups cross-linked by N,N'-p-phenylenedimaleimide (pPDM) was found
Preparation and properties of FabIgG, a chimeric univalent antibody designed to attack tumour cells.
G T Stevenson et al.
Bioscience reports, 5(10-11), 991-998 (1985-10-01)
In order to promote the killing of tumour cells by antibody a derivative has been synthesized in which Fab'gamma from xenogeneic antibody is thioether-bonded to half-cystine on normal IgG of the species to be treated. The resulting entity, FabIgG, is
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