RB1
retinoblastoma 1
Synonyms:
OSRC, RB, p105-Rb, pRb, pp110
Species:
Human RB1 (5925), Mouse Rb1 (19645), Rat Rb1 (24708), chicken RB1 (386582), Zebrafish rb1 (777733), domestic cat RB1 (101101356), dog RB1 (476915), cow RB1 (534712), Horse RB1 (100057080), sheep RB1 (100144755) ...More
UniProtKB ID:
Gene ID:
- Human(5925) Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- Mouse(19645) retinoblastoma 1
- Rat(24708) retinoblastoma 1
- chicken(386582) retinoblastoma 1
- Zebrafish(777733) retinoblastoma 1
- domestic cat(101101356) retinoblastoma 1
- dog(476915) retinoblastoma 1
- cow(534712) retinoblastoma 1
- Horse(100057080) retinoblastoma 1
- sheep(100144755) retinoblastoma 1
- Domestic Rabbit(100357431) retinoblastoma 1
- domestic guinea pig(100716297) retinoblastoma 1
- naked mole-rat(101703701) retinoblastoma 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti RB1 Antibody, clone 23GB2535, Rabbit Monoclonal, clone 23GB2535, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human
Application
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-Rb (Ab-5) Mouse mAb (LM95.1), liquid, clone LM95.1, Calbiochem®,
Species Reactivity
human
Application
Anti-Retinoblastoma antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Anti-Retinoblastoma, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Retinoblastoma antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Kits
Product Number
Description
Species
CpG WIZ™ RB1 - Methylation specific PCR assay, MSP, performed using the CpGenome DNA Modification Kit & the CpG WIZ RB1 Amplification Kit, permits sensitive detection of altered DNA.,
Species
human
Proteins
Product Number
Description
Species
Retinoblastoma protein human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Species
human
Retinoblastoma Protein (aa 773-928), Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.,
Species
human