膜色谱法
我们的 Natrix® 色谱膜技术将下游生产效率和灵活性提升到了一个新的水平。其大孔结构结合高官能团密度，可在超快流速下实现高负载能力和出色的杂质去除效果。凭借在一次性使用和可扩展格式下的卓越性能，我们创新的 Natrix® 产品能够提高工艺经济性并提升设施利用率。
Natrix® CH 色谱膜
色谱纯化是生物分子纯化过程中常见的瓶颈。凭借高负载能力和超快流速，我们的 Natrix® 色谱膜以可扩展的一次性使用形式，实现了卓越的杂质去除效果。这项创新技术不仅解决了您面临的诸多纯化难题，还使下游生产效率提升至全新水平，同时提高了工艺经济性并优化了设备利用率。
Natrix® Q 色谱膜
一种高容量、高通量、强阴离子交换膜色谱装置，专为生物分子的流通过滤纯化以及内毒素、病毒、高分子杂质（HCP）和核酸的去除而设计。
Natrix® Q 色谱膜是一种多孔聚丙烯酰胺水凝胶，其惰性、大孔膜支架内直接聚合了高密度的侧链季铵（Q）结合基团。 其相互连通的孔隙结构和高官能团密度，在保持宽范围缓冲液条件下卓越的杂质去除能力的同时，实现了高流速和高负载能力。Natrix® Q 色谱膜装置可提高您的生产效率、灵活性、经济效益和工艺稳定性。
相关网络研讨会
本研究将高结合能力的Natrix® CH阳离子交换水凝胶膜与传统树脂及商用膜进行了对比，结果表明其生产率提高了30倍以上，结合能力提高了5至8倍，且从小规模（1毫升）到生产规模（9至372毫升）的设备中均能保持稳定的性能。
全一次性膜法净化工艺的优势，以及采用创新型膜吸收器进行的大流量精处理。
通过采用膜色谱技术进行工艺强化，在提高病毒纯化收率、生产效率和制造灵活性的同时，降低成本。
了解新型蛋白A亲和膜的优势，该膜作为一种高产率、真正的一次性色谱平台，可用于强化单克隆抗体（mAb）的纯化。
相关文章
- The Natrix® CH chromatography membrane device achieves high binding capacity at fast flow rates for accelerated mAb purification.
- This document lists all the frequently asked questions about Natrix® CH devices.
- Separation and purification of subpopulations of extracellular vesicles (EVs) using Eshmuno® Q anion exchange resin and Natrix® Q membrane chromatography.
相关文件
- Data Sheet: Natrix® CH Chromatography Membrane
For single-use flow through aggregate removal.
- Application Note: Higher Volume Processing Using Natrix® Q Device
This application note describes a series of tests to assess performance of a Mobius® tubing assembly containing two Natrix® Q Process 600 devices manifolded in parallel.
- Guide: Biochromatography Portfolio Guide
Bulk Resin, Membranes and Prepacked Columns
- Guide: Chromatography Product Selection Guide
Protein A Affinity Chromatography Options
- Guide: Natrix® Q Chromatography Membrane
With a revolutionary three-dimensional macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix® membranes deliver binding capacity that exceeds resin-based columns with fast flow rates.
- Data Sheet: Natrix® Q Chromatography Membrane - For single-use, scalable purification
Natrix® chromatography membrane is a high capacity, high throughput strong anion exchange device designed to purify biomolecules.
- Guide: Natrix® Q Chromatography Membrane Best Practices Guide
With an innovative macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix® Q anion exchange (AEX) chromatography membranes deliver higher binding capacities than resin-based columns at fast flow rates typical of traditional membrane adsorbers.
- Application Note: Comparison of process-related impurity clearance for membrane adsorbers and resin-based chromatography technologies
Strong anion exchange (AEX) chromatography has become an industry standard in polishing steps for monoclonal antibody (MAb) purification.
- Application Note: Robust, Load Independent Viral Clearance in Monoclonal Antibody Purification with Natrix® Q Chromatography Membrane
Anion exchange chromatography is an important flowthrough polishing step for viral clearance of monoclonal antibodies (mAbs).
- Brochure: What's Next: Exploring the Future of Bioprocessing Together
Respondents viewed intensified technologies as mostly single use at the clinical-stage and as mostly hybrid at the commercial scale.
