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Merck
CN

T8566

L-Tyrosine

99.0-101.0%, suitable for cell culture, BioXtra, non-animal source

Synonym(s):

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-L-alanine

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About This Item

Linear Formula:
4-(HO)C6H4CH2CH(NH2)CO2H
CAS Number:
60-18-4
Molecular Weight:
181.19
NACRES:
NA.26
PubChem Substance ID:
24900543
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-460-4
MDL number:
MFCD00002606
Beilstein/REAXYS Number:
392441

Key Documents

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Product Name

L-Tyrosine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 99.0-101.0%

assay

99.0-101.0%

form

powder

InChI key

OUYCCCASQSFEME-QMMMGPOBSA-N

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

SMILES string

N[C@@H](Cc1ccc(O)cc1)C(O)=O

biological source

non-animal source

agency

USP/NF
meets EP testing specifications
meets USP testing specifications

product line

BioXtra

optical activity

[α]25/D 11.2 to 9.8°, c = 5 in 1 M HCl (Specific Rotation 6.1 - 7.8 °)

shelf life

limited shelf life, expiry date on the label

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 25 mg/mL

cation traces

Fe: ≤10 ppm
NH4+: ≤0.02%

application(s)

pharmaceutical (small molecule)

functional group

(phenol)

storage temp.

room temp

Quality Level

300

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Features and Benefits

  • Suitable for Cell Culture and Biochemical research
  • High-quality compound suitable for multiple research applications

Biochem/physiol Actions

L-Tyrosine consists of a polar side chain and is a non-essential amino acid. It is utilized by cells to synthesize proteins that are involved in signal transduction. L-Tyrosine acts as a receiver of phosphate groups that are transferred by kinases.

Application

L-Tyrosine has been used as a supplement in Dulbecco′s modified Eagle′s medium for culturing SY5Y neuroblastoma cells for stable isotope labeling of amino acids on cell culture (SILAC).

General description

L-Tyrosine, an essential amino acid, plays a vital role in biochemical and cell culture research. In biochemical studies, L-Tyrosine is significant as a precursor to neurotransmitters like dopamine, norepinephrine, and epinephrine, which influence cellular communication and play a role in mood, attention, and energy levels. It also contributes to the synthesis of thyroid hormones, regulating metabolic processes. L-Tyrosine is employed to support cell growth and protein synthesis, facilitating experiments on cell maintenance and repair, making it a valuable tool in biochemical and cell culture investigations.

Other Notes

Amino acid precursor of dopamine and other catecholamines
For additional information on our range of Biochemicals, please complete this form.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000511048
0000511044
0000511048
0000511044
0000511047

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Altering O-Linked ?-N-Acetylglucosamine Cycling Disrupts Mitochondrial Function
Ee Phie Tan
The Journal of Biological Chemistry, 14719-14730 (2014)
Chemistry, An Introduction to General, Organic, and Biological Chemistry (2016)
John W Hill
Chemistry for Changing Times (2016)
Keisuke Saito et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7690-7695 (2013-04-20)
Using quantum mechanics/molecular mechanics calculations and the 1.9-Å crystal structure of Photosystem II [Umena Y, Kawakami K, Shen J-R, Kamiya N (2011) Nature 473(7345):55-60], we investigated the H-bonding environment of the redox-active tyrosine D (TyrD) and obtained insights that help
Hideki Hara et al.
Nature immunology, 14(12), 1247-1255 (2013-11-05)
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2.
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Articles

L-Tyrosine in Cell Culture

Learn more about the amino acid L-Tyrosine and explore how it is used in cell culture media like MEM, DMEM, and RPMI. We offer a comprehensive portfolio of amino acid cell culture supplements and reagents.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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