T8441
L-苏氨酸
99.0-101.0%, suitable for cell culture, BioXtra, non-animal source
别名:
(2S,3R)-2-氨基-3-羟基丁酸
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关于此项目
线性分子式:
CH3CH(OH)CH(NH2)CO2H
化学文摘社编号:
分子量:
119.12
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-774-1
MDL number:
Beilstein/REAXYS Number:
1721646
产品名称
L-苏氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%
InChI key
AYFVYJQAPQTCCC-GBXIJSLDSA-N
InChI
1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
SMILES string
C[C@@H](O)[C@H](N)C(O)=O
biological source
non-animal source
agency
USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications
product line
BioXtra
assay
99.0-101.0%
form
powder
quality
meets EP, JP, USP testing specifications
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
white
mp
256 °C (dec.) (lit.)
solubility
H2O: 1 g/10 mL, clear, colorless
application(s)
pharmaceutical (small molecule)
Quality Level
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Application
L-苏氨酸已用于以下用途：
- 研究高温对高丝氨酸激酶活性的影响
- Plackett–Burman 分析，以及研究选定氨基酸对 CHO 细胞中单克隆抗体产生的影响
- 作为底物测定 L-苏氨酸脱氢酶活性
- 研究 L-苏氨酸对恶臭假单胞菌生长速率的影响，检查其对 L-苏氨酸的耐受性
Biochem/physiol Actions
L-苏氨酸被认为是一种必需氨基酸。L-苏氨酸参与黏蛋白的合成，黏蛋白是一种支持肠道功能和完整性的蛋白质。L-苏氨酸是免疫系统发挥功能所必需的。对O-连接糖基化、蛋白质磷酸化和甘氨酸合成也是必需的。
General description
L -苏氨酸是一种天然存在的氨基酸，属于天门冬氨酸氨基酸家族。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Systems metabolic engineering of Escherichia coli for L?threonine production.
Lee HK, et al.
Molecular Systems Biology, 3(1), 149-149 (2007)
Regulation of L-Threonine Dehydrogenase in Somatic Cell Reprogramming
Chuanchun Han
Stem Cells, 31(5) (2013)
Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.
Gonzalez-Leal IJ
Biotechnol. Progress, 27(6), 1709-1717 (2011)
Genome-wide identification of tolerance mechanisms toward p-coumaric acid in Pseudomonas putida
Patricia Calero
Biotechnology and Bioengineering, 115(3), 762-774 (2018)
Homoserine Kinase from Escherichia coli K-12: Properties,
Inhibition by L-Threonine, and Regulation of Biosynthesis
Inhibition by L-Threonine, and Regulation of Biosynthesis
J. THEZE
Journal of Bacteriology, 118(2), 577-581 (1974)
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