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方案
≥98% (HPLC)
表单
powder
颜色
dark green to black
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CN(C1=CC(OC)=C(OC)C(OC)=C1)C2=C3C(C=CC(C(F)(F)F)=C3)=NC=C2
InChI
1S/C20H19F3N2O3/c1-25(13-10-17(26-2)19(28-4)18(11-13)27-3)16-7-8-24-15-6-5-12(9-14(15)16)20(21,22)23/h5-11H,1-4H3
InChI key
PVTQCCFMFWASHK-UHFFFAOYSA-N
生化/生理作用
Negative control analog for the cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 (CA93).
SGC-GAK-1N (CA71) is a structure analog of and the recommended negative control for the ATP-competitive cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 (CA93) (GAK KD = 1.9 nM/SGC-GAK-1 vs. 7.1 μM/SGC-GAK-1N by ligand competitive binding assay; GAK IC50 = 110 nM/SGC-GAK-1 vs. >50 μM/SGC-GAK-1N by cellular target engagement assay; Dengue viral entry and packaging IC50 = 920 nM/SGC-GAK-1 vs. >10 μM/SGC-GAK-1N). For characterization details of the active probe, SGC-GAK-1, please visit the SGC-GAK-1 probe summary on the Structural Genomics Consortium (SGC) website.
SGC-GAK-1, the active probe, is available from Sigma. To learn more about and purchase SGC-GAK-1, click here.
To learn about other SGC chemical probes, visit sigma.com/sgc
SGC-GAK-1, the active probe, is available from Sigma. To learn more about and purchase SGC-GAK-1, click here.
To learn about other SGC chemical probes, visit sigma.com/sgc
特点和优势
SGC-GAK-1N is a negative control for SGC-GAK-1, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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