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Merck
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SAB3500380

Anti-LXR-B antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-LXRB, Anti-Liver X receptor B, Anti-NR1H2, Anti-Nuclear receptor subfamily 1 group H member 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

P55055

UniProt accession no.

P55055

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NR1H2(7376)

Related Categories

General description

Liver X receptor β (LXRβ ) is a member of LXRs that belong to the nuclear receptor superfamily. It possesses a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity. The protein is expressed in many tissues and the LXRβ gene is localized on human chromosome 19q13.3.

Immunogen

LXR-B antibody was raised against a 14 amino acid peptide from near the amino terminus human LXR-B.

Biochem/physiol Actions

Liver X receptor β (LXRβ) has a role in cell death and cholesterol metabolism. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500380.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
55791001

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Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells.
Derangere V
Cell Death and Differentiation (2014)
A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.
Mouzat K
BMC Medical Genetics (2011)
Liver x receptors in atherosclerosis and inflammation.
Im SS and Osborne TF
Circulation Research (2011)

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