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安全信息

P3201

Sigma-Aldrich

Platelet-Derived Growth Factor-BB 人

≥98% (HPLC and SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

PDGF-BB

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选择尺寸

2.5 MG
CN¥5,658.94

CN¥5,658.94

预计发货时间May 12, 2025详情

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2.5 MG
CN¥5,658.94

About This Item

MDL编号:
MFCD00213023
UNSPSC代码:
12352202
NACRES:
NA.77

CN¥5,658.94

预计发货时间May 12, 2025详情

产品名称

Platelet-Derived Growth Factor-BB 人, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

生物来源

human

质量水平

200

重组

expressed in E. coli

方案

≥98% (HPLC and SDS-PAGE)

表单

lyophilized powder

效能

1.0-3.0 ng/mL EC50

质量

endotoxin tested

分子量

~25 kDa

包装

pkg of 10 μg
pkg of 50 μg

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Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

form

powder

form

liquid

form

-

form

liquid

mp

118-120 °C (lit.)

mp

1.5-2.5 °C (lit.)

mp

-

mp

-

一般描述

Platelet-derived growth factor (PDGF) is expressed as homo and heterodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.[1] The PDGF gene is highly conserved mapped to human chromosome 7p22.3.[2][3] The active form of Pdgf exists as disulfide-linked dimers. It consists of cystine-knot-fold growth factor domain, which is highly conserved, except for the N-terminal prodomain, which shows variation in length among the isoforms.[4]

应用

Platelet-Derived Growth Factor-BB human has been used :
  • As a growth supplement in proximal tubule and glomerular explant cell culture[5]
  • In three-dimensional scaffold preparation[6]
  • To study the effect of brivanib on growth factor signaling pathways[7]
  • In transwell migration assay[8]

生化/生理作用

Platelet-derived growth factor (PDGF) elicits multifunctional actions with a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells, and chondrocytes.[9] PDGF significantly activates chemotaxis of neutrophils, monocytes, and fibroblasts.[10][9] It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins, and modulates LDL (low density lipoprotein) receptor binding.
PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair.[11] PDGF-BB isomer is found to be critical in angiogenesis and is highly expressed in tumor, mediating oncogenic pericyte recruitment.[1] PDGF-BB is an important regulator of bone homeostasis, repair and regeneration.[12]

其他说明

Dimer of the B chain of human PDGF.

外形

Lyophilized from a 0.2 μm filtered solution in 30 mM acetic acid.

分析说明

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000417799
    0000417799
    0000410551
    0000410551
    0000375947

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    Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts
    Antoniades HN
    Proceedings of the National Academy of Sciences of the USA, 88.2, 565-569 (1991)
    Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury.
    Szczypka MS, et al.
    Stem Cells, 23.1, 44-54 (2005)
    Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling.
    Nakamura I, et al.
    PLoS ONE, 9.4 (2014)
    Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.
    Kohannim O,et al.
    Case Reports in Genetics, 2011 , 1-6 (2011)
    Yasutoshi Takashima et al.
    American journal of physiology. Renal physiology, 310(5), F395-F408 (2016-01-15)
    Glomerular integrity and functions are maintained by growth factor signaling. Heparan sulfate, the major component of glomerular extracellular matrixes, modulates growth factor signaling, but its roles in glomerular homeostasis are unknown. We investigated the roles of heparan sulfate 6-O-endosulfatases, sulfatase
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