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Merck
CN

C6852

L-Cysteine hydrochloride monohydrate

98.5-101.0% dry basis, suitable for cell culture, non-animal source, meets EP, USP testing specifications

Synonym(s):

L-Cysteine hydrochloride hydrate (1:1:1)

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About This Item

Linear Formula:
HSCH2CH(NH2)COOH · HCl · H2O
CAS Number:
7048-04-6
Molecular Weight:
175.63
NACRES:
NA.26
PubChem Substance ID:
24892902
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-157-7
MDL number:
MFCD00065606
Beilstein/REAXYS Number:
5158059

Key Documents

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Product Name

L-Cysteine hydrochloride monohydrate, from non-animal source, suitable for cell culture, meets EP, USP testing specifications

InChI key

QIJRTFXNRTXDIP-JIZZDEOASA-N

InChI

1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1

SMILES string

O.Cl.N[C@@H](CS)C(O)=O

biological source

non-animal source

agency

meets EP testing specifications
meets USP testing specifications

assay

98.5-101.0% dry basis

form

powder or crystals

optical activity

[α]20/D 6.1 to 7.8°, c = 8 in 1 M HCl
[α]25/D 5.7 to 6.8°, c = 8 in HCl (6 N)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

solubility

water: 1 g/10 mL, clear, colorless

cation traces

Fe: ≤10 ppm
NH4+: ≤0.02%

application(s)

pharmaceutical (small molecule)

functional group

(sulfhydryl)

storage temp.

room temp

Quality Level

300

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Related Categories

Application

L-Cysteine hydrochloride monohydrate has been used as a component of yeast dropout media for culturing yeasts. It has also been used as a component of differential reinforced clostridial broth (DRCM) for the isolation of clostridia.

Biochem/physiol Actions

Cysteine (Cys) is a sulfur-containing amino acid that modulates metabolism for growth, reproduction and immunity. It provides the disulfide linkage in proteins and in involved in the transport of sulfur. Cysteine is involved in the formation of hydrogen sulfide that functions as a signaling molecule. Cys residues are present at the catalytic sites of various enzymes.
NMDA glutamatergic receptor antagonist.

Features and Benefits

  • Suitable for Cell Culture and Biochemical research
  • High-quality compound suitable for multiple research applications

General description

L-Cysteine hydrochloride, commonly referred to as Cysteine HCl, is a vital component in biochemical research due to its versatile roles. Derived from the naturally occurring amino acid L-cysteine, this compound plays a crucial part in redox reactions, protein structure, cell culture, and antioxidant activity. Cysteine HCl functions as a reducing agent and a nucleophile in redox reactions. Additionally, it serves as a precursor to glutathione, a potent cellular antioxidant. Its significance extends to protein structure, where it contributes to the formation of disulfide bonds that stabilize protein structures. Cysteine HCl also supports cell growth and viability in cell culture applications. Its widespread applications encompass diverse areas of biochemical research, including redox biology, protein biochemistry, cell biology, and antioxidant investigations.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000501637
0000501635
0000501637
0000501635
0000485232

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Protocol for the selection of single-domain antibody
fragments by third generation intracellular
antibody capture
Tomoyuki Tanaka & Terence H Rabbitts
Nature (2009)
Richard S. Lord, J. Alexander Bralley
Laboratory Evaluations for Integrative and Functional Medicine (2008)
Salma Alavi et al.
STAR protocols, 1(3), 100200-100200 (2020-12-31)
The gut microbiome plays an important role in the exclusion of pathogens and, thus, infection outcomes. Microbiome-pathogen interaction studies are complicated by a lack of tractable animal models and differences in animal model versus human microbiomes. We have adapted the
Durga P Neupane et al.
PLoS pathogens, 18(8), e1010731-e1010731 (2022-08-13)
Children are particularly susceptible to typhoid fever caused by the bacterial pathogen Salmonella Typhi. Typhoid fever is prevalent in developing countries where diets can be less well-balanced. Here, using a murine model, we investigated the role of the macronutrient composition
Hye Mi Kim et al.
Toxins, 13(10) (2021-10-23)
Patulin, a mycotoxin, is known to have cytotoxic effects, but few studies have focused on the involvement of the endoplasmic reticulum (ER) stress response in patulin toxicity and the natural compounds that attenuate it in HepG2 cells. This study tested
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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

L-Cysteine in Cell Culture

Importance and uses of cysteine in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

L-半胱氨酸在细胞培养中的应用

半胱氨酸在无血清真核细胞培养中的重要性和应用，包括杂交瘤细胞和中国仓鼠卵巢（CHO）细胞培养

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

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