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HLPPMAG-57K

Millipore

MILLIPLEX® 人肝蛋白磁珠板 - 代谢多重检测

The Human Liver Protein Panel, using the Luminex xMAP technology, enables the simultaneous analysis of 9 liver protein biomarkers in human serum, plasma and tissue/cell culture samples.

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.47

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 100.2%
(HGF)
accuracy: 93.7%
(ANGPTL3)
accuracy: 94.2%
(AFP)
accuracy: 96.6%
(FGF-23)
accuracy: 96.8%
(ANGPTL4)
accuracy: 98.8%
(FGF-21)
sensitivity: 0.004 ng/mL
(MinDC+2SD; FGF-21)
sensitivity: 0.014 ng/mL
(MinDC+2SD; FGF-23)
sensitivity: 0.018 ng/mL
(MinDC+2SD; HGF)
sensitivity: 0.054 ng/mL
(MinDC+2SD; FGF-19)
sensitivity: 0.144 ng/mL
(MinDC+2SD; AFP)
sensitivity: 0.218 ng/mL
(MinDC+2SD; FABP1)
sensitivity: 0.725 ng/mL
(MinDC+2SD; ANGPTL3)
sensitivity: 0.847 ng/mL
(MinDC+2SD; ANGPTL6)
sensitivity: 2.150 ng/mL
(MinDC+2SD; ANGPTL4)
standard curve range: 0.01-10 ng/mL
(FGF-21)
standard curve range: 0.04-30 ng/mL
(FGF-23)
standard curve range: 0.07-50 ng/mL
(HGF)
standard curve range: 0.14-100 ng/mL
(AFP)
standard curve range: 0.14-100 ng/mL
(FGF-19)
standard curve range: 0.27-200 ng/mL
(FABP1)
standard curve range: 0.69-500 ng/mL
(ANGPTL3)
standard curve range: 1.37-1000 ng/mL
(ANGPTL6/AGF)
standard curve range: 5.49-4000 ng/mL
(ANGPTL4)
inter-assay cv: <20%
intra-assay cv: <10%
(AFP)
inter-assay cv: <20%
intra-assay cv: <10%
(ANGPTL3)
inter-assay cv: <20%
intra-assay cv: <10%
(ANGPTL4)
inter-assay cv: <20%
intra-assay cv: <10%
(ANGPTL6/AGF)
inter-assay cv: <20%
intra-assay cv: <10%
(FABP1)
inter-assay cv: <20%
intra-assay cv: <10%
(FGF-19)
inter-assay cv: <20%
intra-assay cv: <10%
(FGF-21)
inter-assay cv: <20%
intra-assay cv: <10%
(FGF-23)
inter-assay cv: <20%
intra-assay cv: <10%
(HGF)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

肝分泌蛋白通过调节循环脂蛋白水平，能量消耗，葡萄糖代谢和脂肪酸摄取，在代谢稳态中发挥重要作用。肝脏分泌的蛋白质可以作为肝脏疾病和胃癌的生物标志物。肝蛋白的准确测量对于了解其生物学功能至关重要。

MILLIPLEX®人肝蛋白检测试剂盒是一种9重试剂盒，用于同时定量血清、血浆和组织/细胞培养样本中以下分析物的任何或全部：AFP，ANGPTL3，ANGPTL4，ANGPTL6/AGF，FABP1/L-FABP，FGF-19，FGF-21，FGF-23和HGF。

注：当测定ANGPTL6/AGF时，建议使用血清样品。

该试剂盒采用96孔板，包含冻干标准混合物、两个内部检测质控品，可最多可测定38份样本，重复两次。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样本量。

面板类型：代谢

特异性

交叉反应
ANGPTL6标准品与ANGPTL4分析的交叉反应性小于2%。 对于全部其他分析物，一种分析物的抗体与本检测条中的任何其他分析物之间不存在或可忽略的交叉反应性。

应用

  • 分析物：α-甲胎蛋白（AFP）、ANGPTL3、ANGPTL4、ANGPTL6（AGF）、FABP1（L-FABP）、FGF-19、FGF-21、FGF-23、HGF
  • 推荐样本类型: 人血清、血浆和细胞/组织培养上清液或裂解液
  • 注释：测量ANGPTL6/AGF时建议使用血清样品
  • 推荐的样品稀释度：每孔12.5 μL 1:2稀释的血清或血浆。细胞/组织培养样品可以未经稀释或在对照培养基中适当稀释使用。
  • 分析运行时间：为了获得最佳灵敏度，建议在2-8℃下过夜（16-18小时）。也可以在室温（20-25℃）下使用2小时。
  • 研究类别：代谢
  • 研究子类别：代谢紊乱

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

包装

96孔板
单个试剂盒即可满足您的所有需求。

储存及稳定性

试剂盒组分建议的存储温度为2-8°C。

其他说明

请联系技术服务部进行稀释度线性研究。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

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Manjunath Ramanjaneya et al.
Frontiers in endocrinology, 11, 568500-568500 (2020-10-27)
Background: The fibroblast growth factors (FGF) 19 subfamily, also referred to as endocrine FGFs, includes FGF19, FGF21, and FGF23 are metabolic hormones involved in the regulation of glucose and lipid metabolism. Fetuin-A is a hepatokine involved in the regulation of
Nigel Davies et al.
Molecular therapy. Nucleic acids, 24, 369-384 (2021-04-20)
Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of patient self-administration and hence long-term chronic treatment that could enable messenger
Imad Tarhoni et al.
Journal of immunoassay & immunochemistry, 39(1), 84-98 (2018-01-09)
Angiogenesis is associated with tumor progression in a range of malignancies. Herein, we develop custom immunobead assays for several mechanistically important targets and evaluated these against sera from cohorts of non-small cell lung cancer (NSCLC) patients. Antigen "capture" antibodies for
Stefano Bartesaghi et al.
Molecular therapy. Nucleic acids, 28, 500-513 (2022-05-21)
Fibroblast growth factor 21 (FGF21) is a promising therapeutic agent for treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). We show that therapeutic levels of FGF21 were achieved following subcutaneous (s.c.) administration of mRNA encoding human FGF21 proteins.

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