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Human complement multiplex kit, Luminex human complement immunoassay, Millipore human complement panel, Human membrane attack complex,, human MAC panel, Luminex human complement panel, terminal complement complex, MAC, membrane attack complex
推荐产品
种属反应性
human
质量水平
参数
25 μL sample volume (per well diluted sample)
assay range
recovery range: 100%
(same day assay)
recovery range: 120%
(overnight assay)
inter-assay cv: ≤15%
intra-assay cv: ≤15%
standard curve range: 0.6-450 ng/mL
技术
multiplexing: suitable
检测方法
fluorometric (Luminex® xMAP®)
运输
wet ice
储存温度
2-8°C
一般描述
The complement system consists of many plasma proteins that assist, or complement, the ability of phagocytic cells and antibodies to clear pathogens. Although it is part of the innate immune system, it can be recruited and activated by the adaptive immune system. The complement proteins and glycoproteins that are synthesized primarily by hepatocytes normally circulate as inactive pro-proteins. Once stimulated the result of the cascade is a massive amplification of response and activation of the membrane attack complex (C5b-9), which forms a transmembrane pore causing osmotic lysis of target cells. The complement pathway may also form soluble C5b-9, as well as intermediate isoforms, stabilized by regulatory proteins. These soluble complexes are unable to insert into the lipid membrane, and their role in complement pathways is an area of ongoing research.
Research category : Inflammation & Immunology
Research sub-category : Inflammation & Autoimmune Mechanisms; Inflammation
Research category : Inflammation & Immunology
Research sub-category : Inflammation & Autoimmune Mechanisms; Inflammation
特异性
Cross-Reactivity between C5b-9 and other complement proteins found in MILLIPLEX® Human Complement Expanded panel 1 (Cat. No. HCMPEX1-19K) and MILLIPLEX® Human Complement Panel 2 (Cat. No. HCMP2MAG-19K) was tested. There was no or negligible cross-reactivity between the antibody pair in this panel for any of the analytes tested.
应用
MILLIPLEX® Human Complement C5b-9 – Singleplex Magnetic Bead Panel is a Singleplex kit to be used for the quantification of the following analyte in serum, plasma, or cell culture supernatant samples: C5b-9 (Membrane Attack Complex, Terminal Complement Complex).
特点和优势
Everything you need in a single kit
法律信息
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
警示用语:
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
靶器官
Respiratory Tract
WGK
WGK 3
法规信息
新产品
相关内容
Guide on selecting immunoassay platforms including multiplex vs. singleplex assays, instruments, software, and services.
Immunology multiplex assays like MILLIPLEX® allow simultaneous investigation of immune biomarkers, saving time and resources in research.
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