03-0206-00
SMC® Human SNAP-25 High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Human SNAP-25 in human serum, plasma, and cerebrospinal fluid (CSF)
Synonym(s):
SNAP-25 Single Molecule Counting kit, SNAP-25 immunoassay kit, SNAP-25 ultra-sensitive immunoassay, Synaptosomal-associated protein 25 immunoassay kit
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About This Item
Quality Level
product line
SMC®
usage
kit sufficient for 96 wells
species reactivity
human
manufacturer/tradename
SMC®
technique(s)
single molecule counting: suitable
input
serum
plasma (K2 EDTA)
cerebrospinal fluid (CSF)
UniProt accession no.
compatibility
for use with FemtoQuest™ and SMCxPRO® instruments
shipped in
wet ice
storage temp.
2-8°C
General description
SNAP-25 has been implicated in various conditions, including Alzheimer′s disease, schizophrenia, and multiple sclerosis. Abnormalities in SNAP-25 expression or function can disrupt synaptic transmission, leading to impaired neuronal communication and contributing to cognitive decline and other symptoms associated with these disorders. Alterations in SNAP-25 levels often correlate with disease severity, highlighting its importance in neuroinflammation and synaptic dysfunction. Understanding the role of SNAP-25 in these processes can help identify potential therapeutic targets and inform strategies aimed at restoring synaptic function and improving outcomes for neurological disorders.
Application
Biochem/physiol Actions
Non-Human Primate (n=4)
Canine (n=4)
Feline (n=4)
Rat (n=4)
Mouse (n=4)
Note: This assay was tested for cross-reactivity with SNAP-23, STX1A, and NFL. No cross-reactivity was detected with any of these analytes.
Features and Benefits
- Improved options for sample prep and incubation
- Lyophilization protein standard for uniform shipping and storage condition
- Increased reagent volumes to accommodate automation
- Rigorously developed to achieve accurate and reproducible performance on the state-of-the-art SMCxPRO® ultrasensitive immunoassay system.
- Ultra-Sensitive Measurement: Accurately detects SNAP-25 at femtogram per milliliter levels in serum, plasma and CSF.
- Reliable Data: An improved signal-to-noise ratio extends the dynamic range to guarantee precise and trustworthy assay results.
- Easy to Adopt: Follow a well-known sandwich immunoassay protocol to seamlessly incorporate SMC®technology into research processes.
- Automated Workflow: Designed for compatibility with automated liquid handling systems, this assay minimizes manual tasks and enhances laboratory efficiency.
- Expert Support: Get technical assistance from specialized field scientists and technical teams.
Packaging
Analysis Note
- Sensitivity: LLOQ 260 fg/mL* (SMCxPRO® Instrument)
- Standard Curve Range: 130-300,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Serum: 112% Plasma: 110% CSF: 97%
- Recovery: Serm: 82% Plasma: 91% CSF: 89%
Legal Information
Disclaimer
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Regulatory Information
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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