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Merck
CN

TTN

titin

别名:
CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD
物种:
Human TTN (7273), Mouse Ttn (22138), Rat Ttn (84015), chicken TTN (424126), dog TTN (478819), dog TTN (478820), domestic cat TTN (101080315), domestic cat TTN (751825), cow TTN (540561), Domestic Rabbit TTN (100008570) ...展开
UniProtKB ID:
Q8WZ42, A6NKB1, E7EQE6, E7ET18, K7ENY1, Q10465, Q10466, Q15598
基因ID:
  • Human(7273) Summary: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
  • Mouse(22138) titin
  • Rat(84015) titin
  • chicken(424126) titin
  • dog(478819) titin
  • dog(478820) titin
  • domestic cat(101080315) titin
  • domestic cat(751825) titin
  • cow(540561) titin
  • Domestic Rabbit(100008570) titin
  • sheep(101122837) titin
  • domestic guinea pig(100722767) titin
  • naked mole-rat(101717863) titin

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Antibodies

货号
说明
物种反应性
应用
T9030
单克隆抗-肌联蛋白 小鼠抗, clone T11, ascites fluid,
物种反应性
chicken, vertebrates
应用
electron microscopy
immunofluorescence
immunohistochemistry
western blot
SAB1400284
Monoclonal Anti-TTN antibody produced in mouse, clone 7D3, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
HPA007042
Anti-TTN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
MABT75
Anti-Titin (NT/Z-domain) Antibody, clone 17D11.1, clone 17D11.1, from mouse,
物种反应性
human, mouse
应用
immunohistochemistry
western blot
MAB1553
抗肌联蛋白抗体，克隆9B9, culture supernatant, clone 9B9, Chemicon®,
物种反应性
human
应用
immunohistochemistry
western blot