TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
别名:
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
物种:
Human TNFSF11 (8600), Mouse Tnfsf11 (21943), Rat Tnfsf11 (117516), domestic guinea pig Tnfsf11 (100713226), dog TNFSF11 (609418), cow TNFSF11 (513836), naked mole-rat Tnfsf11 (101696350), chicken TNFSF11 (428067), Zebrafish tnfsf11 (100331628)
UniProtKB ID:
基因ID:
- Human(8600) Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
- Mouse(21943) tumor necrosis factor (ligand) superfamily, member 11
- Rat(117516) tumor necrosis factor (ligand) superfamily, member 11
- domestic guinea pig(100713226) tumor necrosis factor (ligand) superfamily, member 11
- dog(609418) tumor necrosis factor (ligand) superfamily, member 11
- cow(513836) tumor necrosis factor (ligand) superfamily, member 11
- naked mole-rat(101696350) tumor necrosis factor (ligand) superfamily, member 11
- chicken(428067) tumor necrosis factor (ligand) superfamily, member 11
- Zebrafish(100331628) tumor necrosis factor (ligand) superfamily, member 11
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Antibodies
货号
说明
物种反应性
应用
抗-RANKL抗体（克隆6A12.1）, clone 6A12.1, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-RANKL/TNFSF11 Antibody, clone 1H17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
bovine, human, monkey, porcine
应用
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TNFSF11 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-TNFSF11 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Proteins
货号
说明
物种
RANK 配体 来源于小鼠, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture,
物种
mouse
sRANKL 人, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
物种
human
RANK Ligand/TRANCE human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
物种
human
可溶性 RANK 配体 (sRANKL) 蛋白，重组人, The recombinant human sRANKL protein is produced in E. Coli.,
物种
human
sRank Ligand from rat, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
物种
rat
esiRNA
货号
说明
物种