SHC1
SHC (Src homology 2 domain containing) transforming protein 1
别名:
SHC, SHCA
物种:
Human SHC1 (6464), Mouse Shc1 (20416), Rat Shc1 (85385), Zebrafish shc1 (323818), naked mole-rat Shc1 (101717434), domestic guinea pig Shc1 (100734561), cow SHC1 (507196), sheep SHC1 (101113548), Horse SHC1 (100063053), domestic cat SHC1 (101092911) ...展开
UniProtKB ID:
基因ID:
- Human(6464) Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Mouse(20416) src homology 2 domain-containing transforming protein C1
- Rat(85385) SHC (Src homology 2 domain containing) transforming protein 1
- Zebrafish(323818) SHC (Src homology 2 domain containing) transforming protein 1
- naked mole-rat(101717434) SHC (Src homology 2 domain containing) transforming protein 1
- domestic guinea pig(100734561) SHC (Src homology 2 domain containing) transforming protein 1
- cow(507196) SHC (Src homology 2 domain containing) transforming protein 1
- sheep(101113548) SHC (Src homology 2 domain containing) transforming protein 1
- Horse(100063053) SHC (Src homology 2 domain containing) transforming protein 1
- domestic cat(101092911) SHC (Src homology 2 domain containing) transforming protein 1
- dog(490439) SHC (Src homology 2 domain containing) transforming protein 1
- chicken(395934) SHC (Src homology 2 domain containing) transforming protein 1
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Antibodies
货号
说明
物种反应性
应用
Anti-p66shc Antibody, clone BG8, ,
物种反应性
human, mouse
应用
immunocytochemistry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-Pan Shc Antibody, clone 3A12.1, clone 3A12.1, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-SHC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
抗-SHC 兔抗, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-phospho-SHC Antibody (Tyr239, Tyr240), from rabbit, purified by affinity chromatography,
物种反应性
bovine, chicken, human, mouse, rat, rhesus macaque
应用
western blot