PSMC1
proteasome (prosome, macropain) 26S subunit, ATPase, 1
别名:
P26S4, S4, p56
物种:
Human PSMC1 (5700), Mouse Psmc1 (19179), Rat Psmc1 (117263), Horse PSMC1 (100062573), chicken PSMC1 (395804), domestic guinea pig Psmc1 (100733985), naked mole-rat Psmc1 (101698658), sheep PSMC1 (101120165), domestic cat PSMC1 (101094025), cow PSMC1 (506238)
UniProtKB ID:
基因ID:
- Human(5700) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
- Mouse(19179) protease (prosome, macropain) 26S subunit, ATPase 1
- Rat(117263) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- Horse(100062573) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- chicken(395804) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- domestic guinea pig(100733985) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- naked mole-rat(101698658) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- sheep(101120165) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- domestic cat(101094025) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- cow(506238) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- dog(100688636) proteasome (prosome, macropain) 26S subunit, ATPase, 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-PSMC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PSMC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PSMC1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
应用
western blot
Small Molecule - Inhibitor
货号
说明
物种
esiRNA
货号
说明
物种