所有图片(1)
About This Item
经验公式（希尔记法）:
C25H39N3O5
CAS号:
分子量:
461.59
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
质量水平
方案
≥90% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: soluble
储存温度
−20°C
SMILES字符串
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
InChI
1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChI key
QEJRGURBLQWEOU-FKBYEOEOSA-N
基因信息
human ... PSMA1(5682) , PSMC1(5700)
mouse ... PSMA1(26440) , PSMC1(19179)
rat ... PSMA1(29668) , PSMC1(117263)
Amino Acid Sequence
Z-Leu-Leu-Nva
生化/生理作用
20S蛋白酶体（Ki=21 nM）和26S蛋白酶体（Ki =35 nM）的有效抑制剂。 用54 μM N-CBZ-Leu-Leu-Norvalinal处理的细胞显示完全阻断G1/S和中期转变的，并并延迟通过S期。 可能是通过稳定的p53的积累诱导大鼠-1和PC12细胞中的凋亡。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Gangwei Ou et al.
PloS one, 4(11), e7806-e7806 (2009-11-13)
Vibrio cholerae is the causal intestinal pathogen of the diarrheal disease cholera. It secretes the protease PrtV, which protects the bacterium from invertebrate predators but reduces the ability of Vibrio-secreted factor(s) to induce interleukin-8 (IL-8) production by human intestinal epithelial
U G Lopes et al.
The Journal of biological chemistry, 272(20), 12893-12896 (1997-05-16)
Proteolysis by the ubiquitin/proteasome pathway controls the intracellular levels of a number of proteins that regulate cell proliferation and cell cycle progression. To determine whether this pathway of protein turnover was also linked to apoptosis, we treated Rat-1 and PC12
Brooke A Jude et al.
Journal of bacteriology, 191(22), 6911-6917 (2009-09-08)
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs in a stepwise fashion, initiating with attachment to the small intestinal epithelium. This attachment is followed by expression of the toxin-coregulated pilus, microcolony formation, and cholera toxin
Yongjian Qiu et al.
Nature communications, 8(1), 1905-1905 (2017-12-05)
Plant phytochromes are thought to transduce light signals by mediating the degradation of phytochrome-interacting transcription factors (PIFs) through the N-terminal photosensory module, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not participate in signaling. Here we show
Takahiko Ishikawa et al.
PloS one, 4(8), e6734-e6734 (2009-08-25)
The type VI secretion system (T6SS) has emerged as a protein secretion system important to several gram-negative bacterial species. One of the common components of the system is Hcp, initially described as a hemolysin co-regulated protein in a serotype O17
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