NUP98
nucleoporin 98kDa
别名:
ADIR2, NUP196, NUP96
物种:
Human NUP98 (4928), Mouse Nup98 (269966), Rat Nup98 (81738), Horse NUP98 (100052986), chicken NUP98 (430616), domestic cat NUP98 (101086674), dog NUP98 (476822), Zebrafish nup98 (777756), domestic guinea pig Nup98 (100716227), sheep NUP98 (101117360) ...展开
UniProtKB ID:
基因ID:
- Human(4928) Summary: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]
- Mouse(269966) nucleoporin 98
- Rat(81738) nucleoporin 98
- Horse(100052986) nucleoporin 98kDa
- chicken(430616) nucleoporin 98kDa
- domestic cat(101086674) nucleoporin 98kDa
- dog(476822) nucleoporin 98kDa
- Zebrafish(777756) nucleoporin 98
- domestic guinea pig(100716227) nucleoporin 98kDa
- sheep(101117360) nucleoporin 98kDa
- Domestic Rabbit(100343626) nucleoporin 98kDa
- naked mole-rat(101704068) nucleoporin 98kDa
- cow(540004) nucleoporin 98kDa
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Antibodies
货号
说明
物种反应性
应用
Anti-Nup98 Antibody, clone 2H10, clone 2H10, from rat,
物种反应性
human, mouse, rat
应用
immunocytochemistry
western blot
western blot
Anti-ADAR2 Antibody, clone 2D1.1, clone 2D1.1, 1 mg/mL, from mouse,
物种反应性
human
应用
immunocytochemistry
western blot
western blot
Anti-NUP98 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-Nup96 Antibody, clone 4H5, clone 4H5, from rat,
物种反应性
mouse
应用
immunocytochemistry
western blot
western blot
Anti-NUP98 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, horse, human, rabbit, rat
应用
western blot
Cell Lines
货号
说明
物种