FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
别名:
FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP
物种:
Human FOLH1 (2346), Mouse Folh1 (53320), Rat Folh1 (85309), chicken FOLH1 (419011), dog FOLH1 (476775), domestic guinea pig Folh1 (100712916), cow FOLH1 (505865), naked mole-rat Folh1 (101725016), Domestic Rabbit FOLH1 (100358060)
UniProtKB ID:
基因ID:
- Human(2346) Summary: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
- Mouse(53320) folate hydrolase 1
- Rat(85309) folate hydrolase 1
- chicken(419011) folate hydrolase (prostate-specific membrane antigen) 1
- dog(476775) folate hydrolase (prostate-specific membrane antigen) 1
- domestic guinea pig(100712916) folate hydrolase (prostate-specific membrane antigen) 1
- cow(505865) folate hydrolase (prostate-specific membrane antigen) 1
- naked mole-rat(101725016) folate hydrolase (prostate-specific membrane antigen) 1
- Domestic Rabbit(100358060) folate hydrolase (prostate-specific membrane antigen) 1
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Antibodies
货号
说明
物种反应性
应用
Anti-PSMA antibody, Mouse monoclonal, clone 107-1A4, purified from hybridoma cell culture,
物种反应性
human
应用
ELISA
flow cytometry
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
flow cytometry
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
Anti-FOLH1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-PSMA antibody, Rabbit monoclonal, clone SP29, recombinant, expressed in proprietary host, tissue culture supernatant,
物种反应性
bovine, dog, human, mouse, pig, rat
应用
immunohistochemistry
Anti-PSMA Antibody, clone 3/A12, clone 3/A12, from mouse,
物种反应性
human
应用
activity assay
flow cytometry
immunofluorescence
inhibition assay
western blot
flow cytometry
immunofluorescence
inhibition assay
western blot
Anti-PSMA/FOLH1 Antibody, clone 3F11, ,
物种反应性
canine, human, mouse, porcine, rat
应用
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Small Molecule - Inhibitor
货号
说明
物种