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Merck
CN

CASP4

caspase 4, apoptosis-related cysteine peptidase

别名:
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
物种:
Human CASP4 (837), Mouse Casp4 (12363), Rat Casp4 (114555), dog CASP4 (403724), naked mole-rat Casp4 (101700797), domestic guinea pig Casp4 (100731032), cow CASP4 (338039)
UniProtKB ID:
P49662, A2NHL8, A2NHM0
基因ID:
  • Human(837) Summary: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(12363) caspase 4, apoptosis-related cysteine peptidase
  • Rat(114555) caspase 4, apoptosis-related cysteine peptidase
  • dog(403724) caspase 4, apoptosis-related cysteine peptidase
  • naked mole-rat(101700797) caspase 4, apoptosis-related cysteine peptidase
  • domestic guinea pig(100731032) caspase 4, apoptosis-related cysteine peptidase
  • cow(338039) caspase 4, apoptosis-related cysteine peptidase

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Antibodies

货号
说明
物种反应性
应用
C1354
抗-半胱天冬酶11单克隆抗体 大鼠抗, clone 17D9, purified from hybridoma cell culture,
物种反应性
mouse
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
MABF265
抗-胱天蛋白酶-4，克隆17D9抗体, clone 17D9, from rat,
物种反应性
human, mouse
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB3500401
Anti-Caspase-4 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
PRS2245
Anti-Caspase-13 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
HPA027588
Anti-CASP4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry

Proteins

货号
说明
物种
C6357
Caspase 4 human, recombinant, expressed in E. coli, 5,000 units/mg protein,
物种
human

esiRNA

货号
说明
物种
EHU156131
MISSION® esiRNA, targeting human CASP4,
物种
human
EMU009871
MISSION® esiRNA, targeting mouse Casp4,
物种
mouse

Small Molecule - Substrate

货号
说明
物种
A9965
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin, ≥95% (HPLC), powder,
物种
rat, mouse, human