推荐产品
生物来源
rat
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
17D9, monoclonal
表单
buffered aqueous solution
种属反应性
mouse
包装
antibody small pack of 25 μL
浓度
~1 mg/mL
技术
immunoblotting: 5-10 μg/mL using mouse EL4 cell extracts.
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Casp4(12363)
一般描述
半胱天冬酶是具有相似结构和底物特异性的蛋白酶，根据其氨基酸序列同源性可分为三个亚家族。单克隆抗半胱天冬酶11（大鼠IgG2a同种型）源自小鼠骨髓瘤细胞与小鼠半胱天蛋白酶11的重组p30亚基免疫的大鼠脾细胞融合产生的17D9杂交瘤。 半胱天冬酶 11（也称为Ich-3）基因编码两个38和43 kDa的蛋白产物，其属于半胱氨酸蛋白酶的Ced3 / ICE家族。半胱天冬酶11是具有长前肽结构域（prodomain）的“上游”半胱天冬酶。半胱天冬酶11已在鼠中鉴定出，并与人半胱天冬酶4和5具有同源性。
免疫原
小鼠半胱天冬酶11的重组p30亚基。
应用
抗半胱天冬酶11单克隆抗体可用于免疫组化和免疫沉淀。它也可用于免疫印迹
生化/生理作用
半胱天冬酶在细胞中通常以没有活性的半胱天冬酶前体的形式生产。胱天冬酶11可以诱导由于过度表达培养的细胞的凋亡。与半胱天冬酶11特异性反应的单克隆抗体是研究蛋白酶网络的有用工具，其参与细胞的发育和调控，并控制着细胞和组织的生死。
外形
溶于含有1% BSA和15 mM叠氮化钠作（pH 7.4）的 .01 M磷酸盐缓冲液。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Qi Zhou et al.
Frontiers in bioengineering and biotechnology, 10, 823933-823933 (2022-03-31)
The communication between macrophages and tendon cells plays a critical role in regulating the tendon-healing process. However, the potential mechanisms through which macrophages can control peritendinous fibrosis are unknown. Our data showed a strong pro-inflammatory phenotype of macrophages after a
Arwa Abu Khweek et al.
Cellular immunology, 370, 104425-104425 (2021-11-21)
Asthma is an inflammatory lung disorder characterized by mucus hypersecretion, cellular infiltration, and bronchial hyper-responsiveness. House dust mites (HDM) are the most prevalent cause of allergic sensitization. Canonical and noncanonical inflammasomes are multiprotein complexes that assemble in response to pathogen
Chuang Yuan et al.
Cell death & disease, 13(8), 722-722 (2022-08-19)
Sepsis is a life-threatening syndrome with disturbed host responses to severe infections, accounting for the majority of death in hospitalized patients. However, effective medicines are currently scant in clinics due to the poor understanding of the exact underlying mechanism. We
Caspase-11: the driving factor for noncanonical inflammasomes
Vigano E and Mortellaro A
European Journal of Immunology, 43(9), 2240-2245 (2013)
Xinyu Yang et al.
Immunity, 51(6), 983-996 (2019-12-15)
Excessive activation of the coagulation system leads to life-threatening disseminated intravascular coagulation (DIC). Here, we examined the mechanisms underlying the activation of coagulation by lipopolysaccharide (LPS), the major cell-wall component of Gram-negative bacteria. We found that caspase-11, a cytosolic LPS receptor, activated the
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