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Merck
CN

1612539

USP

盐酸舍曲林 盐酸盐

United States Pharmacopeia (USP) Reference Standard

别名:

(1S,4S)-4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺 盐酸盐

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关于此项目

经验公式(希尔记法):
C17H17NCl2 · HCl
化学文摘社编号:
分子量:
342.69
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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产品名称

盐酸舍曲林 盐酸盐, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

SMILES string

ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

grade

pharmaceutical primary standard

API family

sertraline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... SLC6A4(6532)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Biochem/physiol Actions

选择性 5-羟色胺再摄取抑制剂,抗抑郁药。

Application

Sertraline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Sertraline Hydrochloride Oral Solution
  • Sertraline Hydrochloride Tablets

General description

Sertraline hydrochloride is a SSRI i.e selective serotonin reuptake inhibitor. It is mainly used in treating psychiatric disorders. It also is effective in treating hypotension occurring in disorders like neurocardiogenic syncope and idiopathic orthostatic hypotension which is affected by autonomic dysfunction.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effect of sertraline hydrochloride on dialysis hypotension.
Dheenan S
American Journal of Kidney Diseases, 31(4), 624-630 (1998)
Aquatic ecotoxicity of the selective serotonin reuptake inhibitor sertraline hydrochloride in a battery of freshwater test species.
Minagh E
Ecotox. Environ. Safety, 72(2), 434-440 (2009)
Marilyn X Zhou et al.
Journal of chromatography. A, 1052(1-2), 13-23 (2004-11-06)
Sertraline is a basic compound and of pharmaceutical application for antidepressant treatment. The compound has two chiral centers. Separation of the three enantiomeric impurities from the parent compound is challenging. In this study, we successfully separated all four stereoisomers by
Melanie L Hedgespeth et al.
Aquatic toxicology (Amsterdam, Netherlands), 151, 84-87 (2014-01-02)
Pharmaceutical residues are increasingly detected in environmental and biological samples, some at levels known to adversely affect non-target organisms; however, less is known of how these organism-level effects relate to the ecology of aquatic systems. Foraging processes may be used
Depression in a Pakistani woman.
Anita Aijaz et al.
The American journal of psychiatry, 171(7), 729-731 (2014-07-02)

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