产品名称
异维甲酸, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
SMILES string
[H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
InChI key
SHGAZHPCJJPHSC-XFYACQKRSA-N
grade
pharmaceutical primary standard
API family
isotretinoin
manufacturer/tradename
USP
mp
172-175 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... RARA(5914), RARB(5915), RARG(5916)
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Analysis Note
这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。
Application
异维甲酸USP参考标准品，预期用途是USP规定的指定质量测试和检测。也用于USP各论，例如：
- 异维甲酸胶囊
- 维甲酸
Biochem/physiol Actions
13-顺式维甲酸(RA)具有抗炎、抗肿瘤作用。RA的作用通过RAR-β和RAR-α受体介导。RA可减弱细胞因子刺激小鼠系膜细胞iNOS的表达和活性。它诱导线粒体膜通透性转变，表现为肿胀和膜电位下降，并通过凋亡途径刺激细胞色素C的释放。这些活性被EGTA和环孢素A逆转。RA也通过增加转录部分增加MMP-1蛋白的表达。
General description
本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。
Other Notes
可能适用相应的销售限制。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Tretinoin
United States Pharmacopeia, 41(4), 4478-4478 (2020)
Isotretinoin Capsules
United States Pharmacopeia, 48(4), 2458-2458 (2023)
Isotretinoin
United States Pharmacopeia, 2457-2457 (2020)
Dimitris Rigopoulos et al.
Clinics in dermatology, 28(1), 24-30 (2010-01-20)
Acne is one of the most prevalent diseases in dermatology: Millions of people worldwide experience this distressing condition. To determine the appropriate therapeutic strategy, there is a strong need for a standardized classification system of acne. The exact molecular mechanism
Antoine Racine et al.
The American journal of gastroenterology, 109(4), 563-569 (2014-02-19)
Isotretinoin, a drug widely prescribed for severe acne, has been suspected to increase the risk of ulcerative colitis (UC), but data are conflicting. To further examine the association between isotretinoin use and risk for UC and Crohn's disease (CD), we
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