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Merck
CN
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文件

1327000

USP

硫酸羟氯喹

United States Pharmacopeia (USP) Reference Standard

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别名:
7-氯-4-[4-（N-乙基-N-b-羟乙基氨基）-1-甲基丁氨基] 喹啉硫酸盐
经验公式（希尔记法）:
C18H26ClN3O · H2SO4
CAS号:
747-36-4
分子量:
433.95
EC 号:
212-019-3
MDL编号:
MFCD00078203
UNSPSC代码:
41116107
PubChem化学物质编号:
329750122
NACRES:
NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

USP

API类

hydroxychloroquine

包装

pkg of 200 mg

制造商/商品名称

USP

储存条件

protect from light

颜色

white to off-white

pH值（酸碱度）

3.5-5.5 (1% in aqueous solution, pH <6.0)

mp

388.4 °F (198°C; 240°C)

溶解性

chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
water: soluble

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

基因信息

human ... TLR7(51284) , TLR9(54106)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Hydroxychloroquine Sulfate is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.

应用

Hydroxychloroquine sulfate USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard and system suitability solutions for assay, impurity analysis, and performance test, according to the given below monographs of United States Pharmacopeia (USP):
  • Hydroxychloroquine Sulfate Tablets
  • Hydroxychloroquine Sulfate
  • Chloroquine Phosphate

生化/生理作用

硫酸羟氯喹是一种抗炎（通过肿瘤坏死因子）、疾病调节抗风湿药物（DMARD）和血红素聚合酶抑制剂。 它可用于治疗疟疾。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H315,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Chloroquine Phosphate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Hydroxychloroquine Sulfate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2) (2021)
Hydroxychloroquine Sulfate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(3) (2022)
Jacques-Eric Gottenberg et al.
JAMA, 312(3), 249-258 (2014-07-17)
Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited. To evaluate the efficacy of hydroxychloroquine
Daniel H Solomon et al.
Arthritis care & research, 66(8), 1246-1251 (2014-01-29)
Observational studies suggest that hydroxychloroquine (HCQ) may reduce the risk of developing diabetes mellitus in patients with rheumatoid arthritis (RA). We examined the effect of HCQ on insulin resistance in subjects without diabetes mellitus with stable RA. Twenty-three RA subjects
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实验方案

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

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