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Merck
CN

1269254

USP

Famotidine Related Compound E

United States Pharmacopeia (USP) Reference Standard

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别名:
N,N′′′-[Dithiobis(methylene-4,2-thiazolediyl)]bisguanidine, 2,2′-[4,4′-Disulfanediylbis(methylene)bis(thiazole-4,2-diyl)]diguanidine
经验公式(希尔记法):
C10H14N8S4
分子量:
374.53
UNSPSC代码:
41116107
NACRES:
NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

USP

API类

famotidine

形式

powder

包装

pkg of 25 mg

制造商/商品名称

USP

储存条件

protect from light

颜色

white

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

InChI

1S/C10H14N8S4/c11-7(12)17-9-15-5(1-19-9)3-21-22-4-6-2-20-10(16-6)18-8(13)14/h1-2H,3-4H2,(H4,11,12,15,17)(H4,13,14,16,18)

InChI key

ZWHJVLVEEDAPHN-UHFFFAOYSA-N

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一般描述

Famotidine Related Compound E (Famotidine Impurity E) is an impurity of famotidine, which is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Famotidine Related Compound E can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.
Also, for use with USP monograph such as Famotidine

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Famotidine
Pharmacopeia, US
United States Pharmacopeia, 39(1)(1-2), 1815-1815 (2020)
RP-HPLC determination of famotidine and its potential impurities in pharmaceuticals
Helali N, et al.
Chromatographia, 60(7-8) (2004)
Potentiometric determination of famotidine in pharmaceutical formulations
Ayad MM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(1-2) (2002)
Photoaffinity labeling of the anionic sites in Caco-2 cells mediating saturable transport of hydrophilic cations ranitidine and famotidine
Bourdet DL, et al.
Journal of medicinal chemistry, 47(11) (2004)

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