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Merck
CN

1269200

USP

法莫替丁

United States Pharmacopeia (USP) Reference Standard

别名:

N′-(氨基磺酰基)-3-([2-(二氨基亚甲基氨基)-4-噻唑基]甲硫基)丙脒

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About This Item

经验公式(希尔记法):
C8H15N7O2S3
CAS号:
分子量:
337.45
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

USP

蒸汽压

<0.0000001 kPa ( 25 °C)

API类

famotidine

表单

powder

包装

pkg of 125 mg

制造商/商品名称

USP

储存条件

protect from light

颜色

white to pale yellow-white

mp

325.4-327.2 °F (163—164°C)

溶解性

DMF: freely soluble
acetone: practically insoluble
chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
ethyl acetate: practically insoluble
glacial acetic acid: freely soluble
methanol: slightly soluble
water: very slightly soluble

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

基因信息

human ... HRH2(3274)

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一般描述

Famotidine is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Famotidine can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.(10)

生化/生理作用

H2组胺受体拮抗剂;抗溃疡剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Simultaneous determination of famotidine and flurbiprofen by high performance liquid chromatography
Hanif M, et al.
Tropical Journal of Pharmaceutical Research, 15(3), 605-611 (2016)
Determination of famotidine in acid reduction tablets by HPTLC and videodensitometry of fluorescence quenched zones
Campbell AN and Sherma J
Journal of Liquid Chromatography and Related Technologies, 26(16), 2719-2727 (2003)
Determination of cimetidine, famotidine, and ranitidine hydrochloride in the presence of their sulfoxide derivatives in pure and dosage forms by high-performance thin-layer chromatography and scanning densitometry
Kelani KM, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 85(5), 1015-1020 (2002)
Stability indicating method for famotidine in pharmaceuticals using porous graphitic carbon column
Helali N and Monser L
Journal of Separation Science, 31(2) (2008)
Development and validation of chromatographic methods for simultaneous determination of ibuprofen and famotidine in presence of related substances in pharmaceutical formulations
Elzanfaly ES, et al.
Acta Chimica Slovenica, 62(1) (2014)

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