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线性分子式:
Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
化学文摘社编号:
分子量:
323.13
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2225532
产品名称
氯霉素，大包装, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
SMILES string
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI key
WIIZWVCIJKGZOK-RKDXNWHRSA-N
grade
pharmaceutical primary standard
API family
chloramphenicol
manufacturer/tradename
USP
mp
149-153 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
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Biochem/physiol Actions
作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Chloramphenicol USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Chloramphenicol
- Chloramphenicol Injection
- Chloramphenicol Capsules
- Chloramphenicol Tablets
- Chloramphenicol Sodium Succinate
- Chloramphenicol Ophthalmic Ointment
- Chloramphenicol Compounded Oral Suspension, Veterinary
- Chloramphenicol Sodium Succinate for Injection
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Ph
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
涉药品监管产品
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