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Merck
CN

1000521

USP

阿卡波糖

United States Pharmacopeia (USP) Reference Standard

别名:

4",6"-二脱氧-4"-([1S]-[1,4,6/5]-4,5,6-三羟基-3-羟甲基-2-环己烯基氨基)-麦芽三糖

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关于此项目

经验公式（希尔记法）:
C25H43NO18
化学文摘社编号:
56180-94-0
分子量:
645.60
NACRES:
NA.24
PubChem Substance ID:
329748872
UNSPSC Code:
41116107
MDL number:
MFCD00869592

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产品名称

阿卡波糖, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1

SMILES string

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O[C@@H]2CO)O[C@H]3[C@H](O)[C@@H](O)[C@H](O)O[C@@H]3CO)[C@H](O)[C@@H](O)[C@@H]1N[C@H]4C=C(CO)[C@@H](O)[C@H](O)[C@H]4O

InChI key

XUFXOAAUWZOOIT-SXARVLRPSA-N

grade

pharmaceutical primary standard

API family

acarbose

form

solid

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... AMY2A(279), MGAM(8972)

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Analysis Note

这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。  ​

Application

阿卡波糖（USP参考标准品）用于USP规定的指定质量测试和检测。也用于USP各论，例如：
  • 阿卡波糖片剂

Biochem/physiol Actions

作为可逆性α-葡萄糖苷酶抑制剂的改性四糖。

Other Notes

可能适用相应的销售限制。
该产品是美国药典生物制品计划的一部分。
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

General description

Acarbose is a pseudotetrasaccharide derived from Actinoplanes species, used as an oral alpha-glucosidase inhibitor in the treatment of type 2 diabetes. It delays carbohydrate digestion and absorption in the intestine. The USP standard facilitates assay precision and impurity profiling by chromatographic analysis.

The USP biologics carbohydrates category includes a variety of carbohydrate-based substances that are essential in the development and manufacturing of therapeutic products. These carbohydrates play crucial roles in biological processes and are often utilized as excipients, stabilizers, or active ingredients in pharmaceuticals. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of carbohydrate therapeutics throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Muhammad Ovais et al.
BMC complementary and alternative medicine, 18(1), 1-1 (2018-01-04)
The medicinal importance of a novel plant Olax nana Wall. ex Benth. (family: Olacaceae) was revealed for the first time via HPLC-DAD finger printing, qualitative phytochemical analysis, antioxidant, cholinesterase, and α-glucosidase inhibitory assays. The crude methanolic extract of O. nana

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