Y102
YC-1
soluble guanylyl cyclase activator, powder
别名:
3-(5′-羟甲基-2′-呋喃基）-1-苄基吲唑
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关于此项目
经验公式（希尔记法）:
C19H16N2O2
化学文摘社编号:
分子量:
304.34
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
YC-1, powder
SMILES string
OCc1ccc(o1)-c2nn(Cc3ccccc3)c4ccccc24
InChI
1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
InChI key
OQQVFCKUDYMWGV-UHFFFAOYSA-N
form
powder
color
white to yellow
solubility
DMSO: 10 mg/mL
H2O: insoluble
Quality Level
Gene Information
human ... PDE5A(8654)
相关类别
Application
Yc-1作为缺氧诱导因子1α （HIF-1α）抑制剂，用于：
- 减少心肌细胞（CM）中缺氧诱导Jagged1的表达
- 研究其对祖细胞扩增、CD34 +和侧群（SP）细胞表型的影响，以及对有能力形成长期菌落形成单位细胞增殖率的影响
- 通过激活Rho / Rho相关蛋白激酶（ROCK）途径，研究其调节对与白蛋白诱导的纤溶酶原激活物抑制剂1（PAI-1）表达结合的1-磷酸鞘氨醇（S1P）表达的调节作用。
Biochem/physiol Actions
YC-1激活可溶性鸟苷酸环化酶，防止血小板聚集和血管收缩。具有治疗循环系统疾病的潜力。Yc-1还具有在体外抑制缺氧诱导因子1α （HIF-1α）活性的能力。可作为潜在的抗血管生成抗癌剂。
可溶性鸟苷酸环化酶的 NO（一氧化氮）非依赖性激活剂。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Kota Wakiyama et al.
Scientific reports, 7(1), 12653-12653 (2017-10-06)
This study aimed to establish a therapeutic strategy targeting hypoxic cancer cells in gastric carcinoma (GC). YC-1 is a HIF-1α inhibitor, and we revealed that low-dose YC-1 (10 µM) suppressed HIF-1α expression, and induced hypoxia-dependent apoptosis in the GC cell line
Michael DeNiro et al.
PloS one, 6(7), e22244-e22244 (2011-07-23)
Retinal neovascularization (NV) is a major cause of blindness in ischemic retinopathies. Previous investigations have indicated that ischemia upregulates GFAP and PDGF-B expression. GFAP overexpression is a hallmark of reactive gliosis (RG), which is the major pathophysiological feature of retinal
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1
Yeo EJ, et al.
Journal of the National Cancer Institute, 95(7), 516-525 (2003)
Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1$\alpha$/Jagged1/Notch1 signaling
Wang K, et al.
Acta Pharmaceutica Sinica. B, 8(5), 795-804 (2018)
Vehicle-dependent effects of sphingosine 1-phosphate on plasminogen activator inhibitor-1 expression
Takahashi C, et al.
Journal of Atherosclerosis and Thrombosis, 37663-37663 (2017)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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