W4262
1400W 二盐酸盐
>98%, potent and selective iNOS inhibitor , solid
别名:
N-（[3-（氨基甲基）苯基]甲基）乙脒 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C10H15N3 · 2 HCl
化学文摘社编号:
分子量:
250.17
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
1400W 二盐酸盐, >98%, solid
Quality Level
assay
>98%
form
solid
storage condition
desiccated
originator
GlaxoSmithKline
shipped in
wet ice
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
InChI
1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChI key
WDJHSQZCZGPGAA-UHFFFAOYSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS3(4846)
Application
使用1400W二氢氯化物：
- 用作诱导型一氧化氮的强抑制剂，分析其对大鼠肠缺血再灌注(I/R)损伤模型的影响
- 用作诱导型一氧化氮合酶(iNOS)选择性抑制剂，说明PM10诱导型内皮功能障碍的机制
- 研究其对大鼠肾缺血/再灌注损伤的疗效
- 作为iNOS抑制剂，研究其在低压缺氧复氧后中和空间记忆障碍的能力
Biochem/physiol Actions
1400W 二盐酸盐是诱导型一氧化氮合酶（iNOS）的有效选择性抑制剂。
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
相关内容
Product Information Sheet
Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
Kesik V, et al.
The Journal of Surgical Research, 157(1), e97-e105 (2009)
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| W4262-10MG | 04061837540820 |