跳转至内容
Merck
CN

W1628

渥曼青霉素

From Penicillium funiculosum, ≥98% (HPLC and TLC), phosphatidylinositol 3-kinase inhibitor, powder

别名:

KY 12420

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C23H24O8
化学文摘社编号:
19545-26-7
分子量:
428.43
NACRES:
NA.77
PubChem Substance ID:
24278777
UNSPSC Code:
12352207
MDL number:
MFCD00133927
Beilstein/REAXYS Number:
67676

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

渥曼青霉素, from Penicillium funiculosum, ≥98% (HPLC and TLC)

InChI key

QDLHCMPXEPAAMD-QAIWCSMKSA-N

SMILES string

[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C3=C2C(=O)c4occ5C(=O)O[C@H](COC)[C@@]3(C)c45

InChI

1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

biological source

Penicillium funiculosum

assay

≥98% (HPLC and TLC)

form

powder

color

off-white

solubility

DMSO: soluble
H2O: unstable

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)

正在寻找类似产品? 访问 产品对比指南

相关类别

Biochem/physiol Actions

渥曼青霉素是一种有效和特异性磷脂酰肌醇 3-激酶（PI3-K）抑制剂，IC50 为 2-4 nM。
渥曼青霉素是一种有效和特异性磷脂酰肌醇 3-激酶（PI3-K）抑制剂，IC50 为 2-4 nM。抑制 PI3-K/Akt 信号转导级联可增强放射或血清剥夺引起的凋亡作用，并阻断细胞因子的抗凋亡作用。渥曼青霉素对 PI3-K 的抑制作用还阻断了胰岛素受体激活引起的许多短期代谢作用。

Features and Benefits

《受体分类和信号转导》手册的G蛋白质（异三聚体）和磷酸肌醇激酶页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸和激酶磷酸酶生物学研究的特色产品。发现更多环核苷酸和激酶磷酸酶生物学特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000462987
0000462987
0000395836
0000334570
0000138034

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Alban R Pereira et al.
Journal of medicinal chemistry, 53(24), 8523-8533 (2010-12-03)
Analogues of the sponge meroterpenoid liphagal have been synthesized and evaluated for inhibition of PI3Kα and PI3Kγ as part of a program aimed at developing new isoform-selective PI3K inhibitors. One of the analogues, compound 24, with IC₅₀ values of 66
S Nakanishi et al.
The Journal of biological chemistry, 267(4), 2157-2163 (1992-02-05)
We have found that a fungal strain, Talaromyces wortmannin KY12420, produces a potent inhibitor of smooth muscle myosin light chain kinase (MLCK). This active product, designated as MS-54, was isolated and purified from the culture broth of the fungus and
Alexander D Crawford et al.
PloS one, 6(2), e14694-e14694 (2011-03-08)
Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. The identification of lead compounds of natural origin would benefit from therapeutically relevant bioassays capable of facilitating the isolation of bioactive molecules from multi-constituent extracts. Towards
Matthew G K Benesch et al.
Journal of lipid research, 56(6), 1134-1144 (2015-04-22)
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also involved in wound healing and inflammation, and in
M Chekenya et al.
Oncogene, 27(39), 5182-5194 (2008-05-13)
Chemoresistance represents a major problem in the treatment of many malignancies. Overcoming this obstacle will require improved understanding of the mechanisms responsible for this phenomenon. The progenitor cell marker NG2/melanoma proteoglycan (MPG) is aberrantly expressed by various tumors, but its
查看所有相关文献

商品

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持