V7264
文拉法辛 盐酸盐
≥98% (HPLC), serotonin-noradrenaline reuptake inhibitor, powder
别名:
(+/-)-1-[2-(二甲基氨基)-1-(4-甲氧基苯基)乙基]环己醇盐酸盐, 盐酸文拉法辛
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关于此项目
经验公式（希尔记法）:
C17H27NO2 · HCl
化学文摘社编号:
分子量:
313.86
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
文拉法辛 盐酸盐, ≥98% (HPLC), powder
SMILES string
Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2
InChI
1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
InChI key
QYRYFNHXARDNFZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
protect from light
color
white
solubility
H2O: >10 mg/mL
originator
Wyeth
Quality Level
Gene Information
human ... SLC6A2(6530), SLC6A4(6532)
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Biochem/physiol Actions
文拉法辛是一种 5-羟色胺-去甲肾上腺素再摄取抑制剂，其 Ki 值分别为 82 和 2480 nM。它是一种普通的抗抑郁药。
文拉法辛是抗抑郁药。文拉法辛在人中的抗抑郁作用机制与其在中枢神经系统中神经递质活性的增强有关。文拉法辛是神经元 5-羟色胺和去甲肾上腺素再摄取的有效抑制剂，是多巴胺再摄取的弱抑制剂。在体外，文拉法辛对毒蕈碱、组胺能或 α-1 肾上腺素能受体无明显活性。文拉法辛不具有 MAO 抑制剂活性。
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
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