生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
26503, monoclonal
形式
lyophilized powder
种属反应性
primate, human
技术
capture ELISA: 2-8 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL
同位素/亚型
IgG2b
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... VEGFA(7422) , VEGFB(7423) , VEGFC(7424)
一般描述
该抗体能够中和重组人VEGF165的生物活性。它也能识别VEGF121。
免疫原
纯化的重组 Sf21-源性人VEGF（165 aa亚型）。
应用
小鼠抗血管内皮生长因子单克隆抗体被用于阻断小牛肺主动脉内皮（CPAE）细胞中VEGF和激酶结构域受体之间的相互作用。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）
蛋白质免疫印迹分析（1篇论文）
生化/生理作用
血管内皮生长因子家族包括五个成员，即从VEGF-A到VEGF-E。它们在胚胎血管形成、血管生成和内稳态中具有重要作用。VEGF与其各自受体之间的相互作用，可激活MAPK、PI3K、PKC、FAK和Src激酶途径。
外形
冻干品来自于以磷酸盐缓冲盐水（含碳水化合物）为溶剂的0.2μm溶液。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Esther Grueso et al.
Journal of virology, 93(19) (2019-07-19)
As many tumor cells synthetize vascular endothelial growth factors (VEGF) that promote neo-vascularization and metastasis, frontline cancer therapies often administer anti-VEGF (α-VEGF) antibodies. To target the oncolytic parvovirus minute virus of mice (MVM) to the tumor vasculature, we studied the
Dong-Kwon Lim et al.
Biomaterials, 77, 130-138 (2015-11-21)
Vascular endothelial growth factor 165 (VEGF165) is an important extracellular protein involved in pathological angiogenesis in diseases such as cancer, wet age-related macular degeneration (wet-AMD) and retinitis pigmentosa. VEGF165 exists in two different isoforms: the angiogenic VEGF165a, and the anti-angiogenic
R Binétruy-Tournaire et al.
The EMBO journal, 19(7), 1525-1533 (2000-04-04)
Vascular endothelial growth factor (VEGF) binding to the kinase domain receptor (KDR/FLK1 or VEGFR-2) mediates vascularization and tumor-induced angiogenesis. Since there is evidence that KDR plays an important role in tumor angiogenesis, we sought to identify peptides able to block
Tania Calvo-López et al.
Frontiers in microbiology, 13, 1063706-1063706 (2023-02-10)
Parvoviruses are promising anticancer and gene therapy agents, but a deep knowledge of the entry process is crucial to exploit their therapeutic potential. We addressed this issue while attempting to retarget the oncolytic parvovirus minute virus of mice (MVMp) to
A Ohwada et al.
Thorax, 58(4), 328-332 (2003-04-02)
Acid induced pneumonitis resulting in acute respiratory distress syndrome (ARDS) is characterised by increased alveolar permeability and accumulation of neutrophils. It is hypothesised that vascular endothelial growth factor (VEGF) is involved in the development of lung oedema. Furthermore, lower levels
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