V4758
血管内皮生长因子单克隆抗体 小鼠抗
clone 26503, purified immunoglobulin, lyophilized powder
别名:
抗VEGF
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关于此项目
Conjugate:
unconjugated
Clone:
26503, monoclonal
Application:
ELISA (c), Neutral, WB
Citations:
14
Quality Level
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
26503, monoclonal
form
lyophilized powder
species reactivity
primate, human
technique(s)
capture ELISA: 2-8 μg/mL, neutralization: suitable, western blot: 1 μg/mL
isotype
IgG2b
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)
General description
该抗体能够中和重组人VEGF165的生物活性。它也能识别VEGF121。
Immunogen
纯化的重组 Sf21-源性人VEGF（165 aa亚型）。
Application
小鼠抗血管内皮生长因子单克隆抗体被用于阻断小牛肺主动脉内皮（CPAE）细胞中VEGF和激酶结构域受体之间的相互作用。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）
蛋白质免疫印迹分析（1篇论文）
Biochem/physiol Actions
血管内皮生长因子家族包括五个成员，即从VEGF-A到VEGF-E。它们在胚胎血管形成、血管生成和内稳态中具有重要作用。VEGF与其各自受体之间的相互作用，可激活MAPK、PI3K、PKC、FAK和Src激酶途径。
Physical form
冻干品来自于以磷酸盐缓冲盐水（含碳水化合物）为溶剂的0.2μm溶液。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Esther Grueso et al.
Journal of virology, 93(19) (2019-07-19)
As many tumor cells synthetize vascular endothelial growth factors (VEGF) that promote neo-vascularization and metastasis, frontline cancer therapies often administer anti-VEGF (α-VEGF) antibodies. To target the oncolytic parvovirus minute virus of mice (MVM) to the tumor vasculature, we studied the
Dong-Kwon Lim et al.
Biomaterials, 77, 130-138 (2015-11-21)
Vascular endothelial growth factor 165 (VEGF165) is an important extracellular protein involved in pathological angiogenesis in diseases such as cancer, wet age-related macular degeneration (wet-AMD) and retinitis pigmentosa. VEGF165 exists in two different isoforms: the angiogenic VEGF165a, and the anti-angiogenic
R Binétruy-Tournaire et al.
The EMBO journal, 19(7), 1525-1533 (2000-04-04)
Vascular endothelial growth factor (VEGF) binding to the kinase domain receptor (KDR/FLK1 or VEGFR-2) mediates vascularization and tumor-induced angiogenesis. Since there is evidence that KDR plays an important role in tumor angiogenesis, we sought to identify peptides able to block
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| V4758-.5MG | 04061832717555 |