U116
U-99194 maleate salt
≥98% (HPLC), solid
别名:
5,6-Dimethoxy-2-(di-n-propylamino)indan maleate salt
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关于此项目
经验公式（希尔记法）:
C17H27NO2 · C4H4O4
化学文摘社编号:
分子量:
393.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
U-99194 maleate salt, ≥98% (HPLC), solid
InChI key
FSIQDESGRQTFNN-BTJKTKAUSA-N
SMILES string
OC(=O)\C=C/C(O)=O.CCCN(CCC)C1Cc2cc(OC)c(OC)cc2C1
InChI
1S/C17H27NO2.C4H4O4/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;5-3(6)1-2-4(7)8/h11-12,15H,5-10H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: >5 mg/mL
Quality Level
Gene Information
human ... DRD3(1814)
Application
U-99194 maleate has been used as a dopaminergic antagonist to study its effects on immobility episodes and yawning frequency in rats.
Biochem/physiol Actions
U-99194 is a putative D3 antagonist with a 30-fold preference for the dopamine D3 vs. D2 receptor.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
U-99194 maleate salt is soluble in water at a concentration >5 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
T Kling-Petersen et al.
Journal of neural transmission. General section, 102(3), 209-220 (1995-01-01)
Compounds showing an in vitro binding preference for the dopamine D3 vs. D2 receptors were tested for effects on locomotor activity after local application in the nucleus accumbens (N Acc) and the ventral tegmental area (VTA) of the rat brain.
Jose R Eguibar et al.
Neuroscience letters, 483(3), 189-192 (2010-08-10)
The taiep rat is a myelin mutant whose immobility episodes (IEs) can be caused by gripping them by the tail. Electroencephalographic recordings during IEs show a rapid-eye movement sleep-like pattern, similar to narcolepsy-cataplexy in canines. Systemic administration of alpha(2)-adrenoceptor agonists
Jose R Eguibar et al.
Pharmacology, biochemistry, and behavior, 102(1), 118-123 (2012-04-14)
Systemic administration of D2-like dopaminergic-receptor agonists increases yawning behavior. However, only a few studies have been done in animals with pathological conditions. The taiep rat is a myelin mutant with an initial hypomyelination followed by progressive demyelination, being the brainstem
N Waters et al.
Journal of neural transmission. General section, 94(1), 11-19 (1993-01-01)
We report on the pharmacological effects of the 20 fold D3 vs. D2 dopamine receptor preferring compound U99194A. It is shown that U99194A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the
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