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U111

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate

Name: (−)-<I>trans</I>-(1S,2S)-U-50488 hydrochloride hydrate
Brand: SIGMA

solid, ≥98% (HPLC)

别名:

trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate

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About This Item

经验公式（希尔记法）:

C₁₉H₂₆Cl₂N₂O · HCl · xH₂O

CAS号:

114528-79-9

分子量:

405.79 (anhydrous basis)

MDL编号:

MFCD11044455

UNSPSC代码:

12352200

PubChem化学物质编号:

24278019

NACRES:

NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

旋光性

[α]22/D -39.0 to -32.0°, c = 0.5 in methanol(lit.)

储存条件

desiccated

颜色

white

溶解性

H₂O: 13 mg/mL

储存温度

2-8°C

SMILES字符串

O.Cl.CN([C@H]1CCCC[C@@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3

InChI

1S/C19H26Cl2N2O.ClH.H2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H;1H2/t17-,18-;;/m0../s1

InChI key

UWPRPWMHQDPOFR-MPGISEFESA-N

基因信息

human ... OPRK1(4986)

应用

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta).

生化/生理作用

Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.

制备说明

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate is soluble in water at 13 mg/ml.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Immunomodulatory activity of mu- and kappa-selective opioid agonists.

D D Taub et al.

Proceedings of the National Academy of Sciences of the United States of America, 88(2), 360-364 (1991-01-15)

Opioids and opioid peptides have been shown by numerous laboratories to modulate various parameters of the immune response, but little attention has been given to the type of opioid receptor that might be involved. This study focuses on the in

Stereospecific inhibition of gastro-intestinal transit by κ-opioid agonists in mice.

Ramabadran, et al.

European Journal of Pharmacology, 155, 329-329 (1991)

Inhibitory and excitatory effects of micro-, delta-, and kappa-opioid receptor activation on breathing in awake turtles, Trachemys scripta.

Stephen M Johnson et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 295(5), R1599-R1612 (2008-09-12)

For ectothermic vertebrates, such as reptiles, the effects of opioid receptor subtype activation on breathing are poorly understood. On the basis of previous studies on mammals and lampreys, we hypothesized that mu- and delta-opioid receptor (MOR and DOR, respectively) activation

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