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U111

Sigma-Aldrich

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate

solid, ≥98% (HPLC)

别名:

trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate

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About This Item

经验公式（希尔记法）:
C19H26Cl2N2O · HCl · xH2O
CAS号:
114528-79-9
分子量:
405.79 (anhydrous basis)
MDL编号:
MFCD11044455
UNSPSC代码:
12352200
PubChem化学物质编号:
24278019
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

solid

旋光性

[α]22/D -39.0 to -32.0°, c = 0.5 in methanol(lit.)

储存条件

desiccated

颜色

white

溶解性

H2O: 13 mg/mL

储存温度

2-8°C

SMILES字符串

O.Cl.CN([C@H]1CCCC[C@@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3

InChI

1S/C19H26Cl2N2O.ClH.H2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H;1H2/t17-,18-;;/m0../s1

InChI key

UWPRPWMHQDPOFR-MPGISEFESA-N

基因信息

human ... OPRK1(4986)

应用

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta).

生化/生理作用

Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.

制备说明

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate is soluble in water at 13 mg/ml.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000370806
0000370808
0000370807
0000370808
0000370807

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Stephen M Johnson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 295(5), R1599-R1612 (2008-09-12)
For ectothermic vertebrates, such as reptiles, the effects of opioid receptor subtype activation on breathing are poorly understood. On the basis of previous studies on mammals and lampreys, we hypothesized that mu- and delta-opioid receptor (MOR and DOR, respectively) activation
Stereospecific inhibition of gastro-intestinal transit by κ-opioid agonists in mice.
Ramabadran, et al.
European Journal of Pharmacology, 155, 329-329 (1991)
D D Taub et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(2), 360-364 (1991-01-15)
Opioids and opioid peptides have been shown by numerous laboratories to modulate various parameters of the immune response, but little attention has been given to the type of opioid receptor that might be involved. This study focuses on the in

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