所有图片(1)
别名:
5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine
经验公式（希尔记法）:
C11H10BrN5
推荐产品
质量水平
溶解性
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
DMSO: >6.5 mg/mL
ethanol: <8 mg/mL (warm)
H2O: insoluble
SMILES字符串
Brc1c(NC2=NCCN2)ccc3nccnc13
InChI
1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChI key
XYLJNLCSTIOKRM-UHFFFAOYSA-N
基因信息
human ... ADRA1A(148) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
正在寻找类似产品? 访问 产品对比指南
应用
UK 14,304 已用于肠肌间神经元，以研究 R 型钙电流的抑制 。UK 14,304 也曾用于免疫荧光显微术分析 。
在心外膜冠状动脉培养中，UK 14,304 已用于激活细胞外信号调节激酶 (ERK)
生化/生理作用
UK 14,304 是 α2-肾上腺素受体激动剂。UK 14,304 抑制激素敏感型脂肪酶 (HSL) 活性并抑制脂肪组织中的脂肪生成。
特点和优势
该化合物在受体分类和信号转导手册中α2-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面， 请单击此处。
制备说明
UK 14,304 可溶于 45%（w/v）aq 2-羟丙基-β--环糊精（<0.8 mg/mL), DMSO (> 6.5 mg/mL）和乙醇（<8 mg/mL）。但它不溶于水。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
J T Turner et al.
Molecular pharmacology, 28(5), 422-430 (1985-11-01)
We have characterized the alpha 2-adrenergic receptor in membranes from the human colonic adenocarcinoma cell line, HT29, using the recently introduced alpha 2-agonist 5-bromo-6-[2-imidazolin-2-yl-amino]quinoxaline [( 3H]UK-14,304), two other radioligands, and a series of adrenergic agonists and antagonists. We also investigated
X Bian et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 19(10), 845-855 (2007-09-22)
Alpha2-adrenoceptors inhibit Ca2+ influx through voltage-gated Ca2+ channels throughout the nervous system and Ca2+ channel function is modulated following activation of some G-protein coupled receptors. We studied the specific Ca2+ channel inhibited following alpha2-adrenoceptor activation in guinea-pig small intestinal myenteric
Juan Wang et al.
Journal of biomedical nanotechnology, 13(9), 1089-1096 (2018-02-27)
In this work, we developed a mildly cross-linked dendrimer hydrogel (mcDH) via
Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
Jensen BC, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 382(5-6), 475-482 (2010)
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.
Francis H, et al.
American Journal of Physiology. Cell Physiology, 293(4), C1252-C1262 (2007)
商品
Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门