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质量水平
溶解性
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
DMSO: >6.5 mg/mL
ethanol: <8 mg/mL (warm)
H2O: insoluble
SMILES字符串
Brc1c(NC2=NCCN2)ccc3nccnc13
InChI
1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChI key
XYLJNLCSTIOKRM-UHFFFAOYSA-N
基因信息
human ... ADRA1A(148) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
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应用
UK 14,304 已用于肠肌间神经元，以研究 R 型钙电流的抑制 。UK 14,304 也曾用于免疫荧光显微术分析 。
在心外膜冠状动脉培养中，UK 14,304 已用于激活细胞外信号调节激酶 (ERK)
生化/生理作用
UK 14,304 是 α2-肾上腺素受体激动剂。UK 14,304 抑制激素敏感型脂肪酶 (HSL) 活性并抑制脂肪组织中的脂肪生成。
特点和优势
该化合物在受体分类和信号转导手册中α2-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面， 请单击此处。
制备说明
UK 14,304 可溶于 45%（w/v）aq 2-羟丙基-β--环糊精（<0.8 mg/mL), DMSO (> 6.5 mg/mL）和乙醇（<8 mg/mL）。但它不溶于水。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha2-adrenoceptor activation by UK 14304.
Shih MF and Taberner PV
Alcohol and Alcoholism (Oxford, Oxfordshire), 36(5), 381-387 (2001)
Kenric Rui-Pin Fan et al.
Acta ophthalmologica, 97(6), e827-e832 (2019-03-28)
To investigate the neuroprotective effect of Copolymer-1 (Cop-1) in patients with acute primary angle closure (APAC) in a randomized double-masked controlled trial. After initial medical management, APAC patients were randomized to receive either subcutaneous Cop-1 or placebo within 24 hr and
Juan Wang et al.
Journal of biomedical nanotechnology, 13(9), 1089-1096 (2018-02-27)
In this work, we developed a mildly cross-linked dendrimer hydrogel (mcDH) via
Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
Jensen BC, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 382(5-6), 475-482 (2010)
Brittany J Carr et al.
Clinical & experimental optometry, 102(4), 418-425 (2019-01-31)
The putative myopia-controlling receptor is thought to be muscarinic acetylcholine receptor subtype M4 , because mamba toxin-3 can inhibit form-deprivation myopia in chicks at a far lower concentration than atropine. However, mamba toxin-3 is equally potent at the human α1A
商品
Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.
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