推荐产品
质量水平
方案
≥99%
表单
powder
颜色
white to off-white
溶解性
DMF: soluble 50 mg/mL
抗生素抗菌谱
fungi
parasites
作用机制
enzyme | inhibits
SMILES字符串
c1ccc2[nH]c(nc2c1)-c3cscn3
InChI
1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChI key
WJCNZQLZVWNLKY-UHFFFAOYSA-N
基因信息
human ... CYP2C9(1559)
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一般描述
化学结构式：咪唑
应用
噻苯唑 (TBZ) 是一种广谱抗蠕虫药，用于治疗人体寄生虫感染。用作农业杀菌剂和食品防腐剂 。噻苯唑已被用作重金属螯合解毒剂。临床上用于治疗线虫病、皮肤幼虫移行症、内脏幼虫移行症及旋毛虫病等 。
生化/生理作用
噻苯唑在线粒体蠕虫特异性酶级别抑制无氧呼吸。在 空肠弯曲菌 和 幽门螺杆菌 中作为一种醌醇富马酸还原酶 (QFR) 抑制剂，阻断醌氧化为醌。噻苯达唑抑制虫卵和幼虫的产生，并可能抑制随粪便排出的虫卵和幼虫的后续发育 。噻苯达唑的一种生物转化途径是 CYP1A2 催化的羟基化反应，生成 5-羟基噻苯达唑，后者被代谢为葡糖苷酸和硫酸盐结合物 。
其他说明
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。储存类别 (TRGS 510)：非易燃固体
警示用语：
Warning
危险声明
预防措施声明
危险分类
Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
法规信息
农药列管产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Roslyn S Thelingwani et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(6), 1286-1294 (2009-03-21)
Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence and presence of NADPH. TDI was observed with both compounds, with k(inact) and K(I) values
Stuart Dashper et al.
Antimicrobial agents and chemotherapy, 54(3), 1311-1314 (2009-12-30)
Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms
Susanne Rath et al.
Chemosphere, 214, 111-122 (2018-09-28)
Brazil is one of the world's largest producers of animal protein, requiring the large-scale use of veterinary drugs. The administration of antimicrobials and antiparasitics is a common practice. However, there is a lack of information on how these drugs impact
Si Young Lee et al.
Cell reports, 30(8), 2686-2698 (2020-02-27)
Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance. We identified factors that form heterochromatin using dense profiles of transposable element integration in
Santosh Soparawalla et al.
The Analyst, 136(21), 4392-4396 (2011-09-06)
We describe a rapid in situ method for detecting agrochemicals on the surface or in the tissue of fruit using a portable mass spectrometer equipped with an ambient ionization source. Two such ionization methods, low temperature plasma (LTP) and paper
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