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Merck
CN

T8535

Monoclonal Anti-β-Tubulin I+II antibody produced in mouse

clone JDR.3B8, ascites fluid

别名:

Anti-CDCBM5, Anti-TUBB, Anti-TUBB2

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00145892

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产品名称

Monoclonal Anti-β-Tubulin I+II antibody produced in mouse, clone JDR.3B8, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

JDR.3B8, monoclonal

contains

15 mM sodium azide

species reactivity

bovine, pig, chicken, human, rat, mouse

packaging

antibody small pack of 25 μL

technique(s)

indirect ELISA: suitable
indirect immunofluorescence: suitable
microarray: suitable
western blot: 1:1,000 using a chicken fibroblast extract or a chicken brain microtubule proteins preparation

isotype

IgG2b

UniProt accession no.

Q13885
Q9H4B7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383)
mouse ... Tubb1(545486), Tubb2a(22151), Tubb2c(227613)
rat ... Tubb2b(291081), Tubb2c(296554)

Application

Monoclonal Anti-β-Tubulin I+II antibody produced in mouse has been used in following studies:
  • immunoblot
  • immunofluorescence technique
  • immunohistochemistry.
Monoclonal Anti-β-Tubulin I+II antibody produced in mouse has been used in:
  • enzyme linked immunosorbent assay (ELISA)
  • immunohistochemistry
  • western blotting
  • immunoblotting
  • dot blot
  • immunocytochemistry

Biochem/physiol Actions

β-1 tubulin, also known as class VI or TUBB1, plays a vital role in platelet production and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP). Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to β-tubulin and inhibits natural killer (NK) cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. Tubulin β 2B class IIb (TUBB2B)/β-tubulin II plays a vital role in migration/organization and axon guidance processes. Mutation in β-tubulin gene is associated with the development of asymmetric polymicrogyria (PMG).
The antibody specifically recognizes an epitope located on isotypes I and II of β-tubulin. No cross-reactivity with other tubulin isotypes is observed.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

β-tubulin belongs to the subfamily of tubulins, which are the major building blocks of microtubules. β-tubulin has a molecular weight of 55kDa. β-tubulin structure is characterized with a core of two β-sheets enclosed by α-helices. In addition, it also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site and a C-terminal domain that contains the binding surface for molecular motor proteins. β-tubulin I and II is encoded by the gene mapped to human chromosome 20 and 6p25.2 respectively.
Monoclonal Anti-β-Tubulin Isotype I + II (mouse IgG2b isotype) is derived from the JDR.3B8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice.

Immunogen

synthetic peptide corresponding to the C-terminal sequence of human β-tubulin isotype II coupled to BSA

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存储类别

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
099M4752V
029M4775V
22181110
045M4836V
033M4762

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Cytoskeleton in action: Lissencephaly, a neuronal migration disorder
Moon HM
Wiley interdisciplinary reviews. Developmental biology, 2, 229-245 (2013)
ABCA3 as a Lipid Transporter in Pulmonary Surfactant Biogenesis
Ban N
The Journal of Biological Chemistry, 282, 9628-9634 (2007)
Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2.
Copley CO
The Journal of Neuroscience, 33, 14001-14016 (2013)
Symmetric polymicrogyria and pachygyria associated with TUBB2B gene mutations.
Guerrini R
European Journal of Human Genetics, 20, 995-998 (2012)
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis
Haughian JM, et al.
International Journal of Cancer. Journal International Du Cancer, 125(11), 2556-2564 (2009)
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Antibodies to Tubulins, including Centrosome-Associated ε-Tubulin

Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.

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