T8453
Anti-β-Tubulin II antibody, Mouse monoclonal
clone 7B9, purified from hybridoma cell culture
别名:
Anti-TUBB2, Anti-Tubulin, β2
产品名称
Anti-β-Tubulin II antibody, Mouse monoclonal, clone 7B9, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
7B9, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human, mouse, rat
concentration
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using Neuro-2a cell extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TUBB2B(347733)
mouse ... Tubb2b(73710)
rat ... Tubb2b(291081)
Application
Anti-β-Tubulin II antibody has been used in
- immunoblotting immunoprecipitation
- immunocytochemistry
- western blotting
- immunolabelling
Biochem/physiol Actions
The αβ tubulins are involved in the formation of microtubules during cell division by the formation of protofilaments.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti- β-Tubulin II (mouse IgG1 isotype) is derived from the hybridoma 7B9 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment at the C-terminus of human β?tubulin II. Tubulin is the major building block of microtubules. This intracellular, cylindrical, filamentous structure is present in almost all eukaryotic cells. Tubulin is a heterodimer that consists of α-tubulin and β ?tubulin. Both subunits have a molecular mass of ~50 kDa and share considerable homology.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Mutations affecting beta-tubulin folding and degradation
Wang Y, et al.
The Journal of Biological Chemistry, 281(19), 13628-13635 (2006)
Hongfeng Yuan et al.
Oncotarget, 8(9), 14912-14924 (2017-01-25)
Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive non-Hodgkin lymphomas. It is curable but one-third of cases are refractory to therapy or relapse after initial response highlighting the urgent need for developing novel therapeutic approaches. Targeting sirtuins
Spatio-temporal dynamics of $\beta$-tubulin isotypes during the development of the sensory auditory organ in rat
Renauld J, et al.
Histochemistry and Cell Biology, 144(5), 403-416 (2015)
FOXP1 potentiates Wnt/ beta-catenin signaling in diffuse large B cell lymphoma
Walker M P, et al.
Science Signaling, 8(362), ra12-ra12 (2015)
Salama A Salama et al.
Fertility and sterility, 98(1), 178-184 (2012-05-15)
To investigate the effects and the mechanism of action of 2-methoxyestradiol (2ME(2)) on transforming growth factor (TGF) β3-induced profibrotic response in immortalized human uterine fibroid smooth muscle (huLM) cells. Laboratory study. University research laboratory. Not applicable. Not applicable. huLM cells
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