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安全信息

T7513

Sigma-Aldrich

凝血酶 来源于牛血浆

lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280 = 19.5)

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别名:
IIa 因子
CAS号:
9002-04-4
EC 号:
3.4.21.5 (BRENDA, IUBMB)
EC 号:
232-648-7
MDL编号:
MFCD00166053
UNSPSC代码:
12352204
NACRES:
NA.54

形式

lyophilized powder

质量水平

200

比活

≥2,000 NIH units/mg protein (E1%/280 = 19.5)

分子量

heavy chain ~33 kDa
light chain ~5 kDa

UniProt登记号

P00735

应用

diagnostic assay manufacturing

储存温度

−20°C

基因信息

cow ... F2(280685)

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生化/生理作用

丝氨酸蛋白酶，选择性断开纤维蛋白原中的精氨酸-甘氨酸键，形成纤维蛋白以及纤维蛋白肽 A 和 B。

单位定义

活性以NIH单位表示，通过与NIH凝血酶参考标准品直接对比确定。

外形

从生理盐水柠檬酸钠缓冲液（pH 6.5）冻干

分析说明

基于 Biggs 改性法的 NIH 分析过程使用 0.2mL 稀释血浆（由血浆与等量生理盐水混合制得）作为底物，以及 0.1mL 凝血酶样品（在含 1% 白蛋白缓冲液中保持稳定）。只使用 15-25 秒之间的凝血时间分析凝血酶浓度。
活性是通过与一种K批次的NIH凝血酶参考标准品进行直接比较而得到并以NIH单位进行表达的。

其他说明

查看更多关于 凝血酶的信息， 请访问 www.sigma-aldrich.com/enzymeexplorer。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

动植物源性产品

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Thrombin Factor IIa

Thrombin Factor IIa is an endolytic serine protease that selectively cleaves the Arg--Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

凝血酶因子IIa

凝血酶因子IIa是一种内切丝氨酸蛋白酶，可选择性地裂解纤维蛋白原的Arg -Gly键，形成纤维蛋白并释放纤维蛋白肽A和B。

实验方案

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

牛血浆凝血酶

凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。

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