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Merck
CN

T7254

Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐

powder, ≥96% (TLC)

别名:

(3S)-1-氯-3-甲苯磺酰氨基-7-氨基-2-庚酮 盐酸盐, (3S)-7-氨基-1-氯-3-甲苯磺酰氨基-2-庚酮 盐酸盐, TLCK, 甲苯磺酰基- L -赖氨酰-氯甲烷 盐酸盐

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关于此项目

经验公式（希尔记法）:
C14H21ClN2O3S · HCl
化学文摘社编号:
4272-74-6
分子量:
369.31
NACRES:
NA.77
PubChem Substance ID:
24278752
UNSPSC Code:
12352202
EC Number:
224-266-4
MDL number:
MFCD00065395
Beilstein/REAXYS Number:
7106867

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产品名称

Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐, ≥96% (TLC), powder

InChI key

YFCUZWYIPBUQBD-ZOWNYOTGSA-N

InChI

1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1

SMILES string

Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl

biological source

synthetic (organic)

assay

≥96% (TLC)

form

powder

potency

10-100 μM effective concentration

solubility

H2O: 50 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... NFKB1(4790), NFKB2(4791)

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Application

Nα-对甲苯磺酰-L-赖氨酸氯甲基酮盐酸盐已用于：
  • 在胰凝乳蛋白酶纯化中抑制粗提液中的胰蛋白酶，从而防止其与亲和载体结合
  • 作为组织和细胞匀浆的蛋白酶抑制剂
  • 作为胰蛋白酶抑制剂测定特定蛋白酶的活性水平

Biochem/physiol Actions

Nα-对甲苯磺酰-L-赖氨酸氯甲基酮盐酸盐(TLCK)抑制脂多糖(LPS)或细胞因子诱导的核因子κB (NF-κB)活化，从而抑制诱导型一氧化氮合酶(iNOS)和环氧合酶(COX-2)的转录激活。它可抑制所有有丝分裂原诱导的pp70s6k激活。还可通过抑制某些细胞株中和刺激下发生的胱天蛋白酶过程而抑制细胞株凋亡。

Disclaimer

20°C 干燥条件下储存时至少可稳定两年。

Packaging

无底玻璃瓶。内含物在插入的融合锥内。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL6071
BCCM0320
BCCL1404
BCCK6452
BCCH0965

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G Kwon et al.
Diabetes, 47(4), 583-591 (1998-05-06)
Interleukin-1beta (IL-1beta) has been implicated as an effector molecule of beta-cell destruction in autoimmune diabetes. IL-1beta inhibits insulin secretion from pancreatic beta-cells by stimulating the expression of inducible nitric oxide synthase (iNOS) that generates the free radical nitric oxide. IL-1beta
Purification and characterization of a serine protease with fibrinolytic activity from the dung beetles, Catharsius molossus
Ahn MY, et al.
Thrombosis Research, 112(5-6), 339-347 (2003)
P Kwo et al.
The American journal of physiology, 268(4 Pt 1), G613-G621 (1995-04-01)
Glycodeoxycholate (GDC) induces apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. In many models of apoptosis, proteolysis is required prior to DNA cleavage. Our aims were to determine if enhanced proteolysis is a mechanism causing GDC-mediated
Swaantje Peters et al.
Cytokine, 40(2), 144-150 (2007-10-26)
Vascular permeability is important at many sites, but particularly so in diabetic retinopathy where macular oedema is the major cause of blindness. Angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) are important factors involved in neovascularization and vascular leakage, but
L Stefanis et al.
Journal of neurochemistry, 69(4), 1425-1437 (1997-11-05)
Rat pheochromocytoma (PC12) cells and sympathetic neurons undergo apoptotic cell death upon withdrawal of trophic support. We have shown previously that selective cysteine aspartase (caspase) inhibitors protect PC12 cells and sympathetic neurons from such death, and that the caspase Nedd-2
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实验方案

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

牛血浆凝血酶

凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。

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