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T6154

Sigma-Aldrich

曲唑酮 盐酸盐

≥99% (HPLC), powder

别名:

2- [3- [4-（3-氯苯基）-1-哌嗪基] 丙基]-1,2,4-三唑 [4,3-a] 吡啶-3 (2H)-酮 盐酸盐

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About This Item

经验公式（希尔记法）:
C19H22ClN5O · HCl
CAS号:
25332-39-2
分子量:
408.32
EC 号:
246-855-5
MDL编号:
MFCD00079603
UNSPSC代码:
12352200
PubChem化学物质编号:
24278136
NACRES:
NA.77

质量水平

200

方案

≥99% (HPLC)

表单

powder

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 23.3 mg/mL
methanol: soluble 25 mg/mL, clear, colorless
0.1 M HCl: soluble 7.4 mg/mL
DMSO: soluble
H2O: soluble, hazy, colorless

创始人

Bristol-Myers Squibb

SMILES字符串

Cl[H].Clc1cccc(c1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2

InChI

1S/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H

InChI key

OHHDIOKRWWOXMT-UHFFFAOYSA-N

基因信息

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2C(3358) , SLC6A4(6532)

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生化/生理作用

增强 5-羟色胺摄取阻断剂活性、并具有完全5-HT 2C 5 羟色胺受体激动剂活性的抗抑郁药。它代谢为 5-HT 1 5-羟色胺受体激动剂 1-（3-氯苯基）哌嗪。

特点和优势

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

制备说明

盐酸曲唑酮溶于 25 mg/mL 甲醇中，得到澄清、无色溶液。在 50 mg/mL 的水中溶解，加热得到浑浊的无色溶液。此外，产品可溶于 DMSO 或 0.1 NHCl (7.4 mg/mL)。在45% (w/v) 2-羟丙基-β-环糊精水溶液中的溶解度为 23.3 mg/mL。然而，它几乎不溶于其他常见有机溶剂。对于 HPLC 检测，本品可以 0.25 mg/mL 溶于 50:50 水：甲醇 (v/v) 中，因为其获得的溶出度和峰形结果优于本品 1 mg/mL 水溶液。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H302,H351

危险分类

Acute Tox. 4 Oral - Carc. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX0553
MKCW9862
MKCR4805
MKCP5549
MKCN6829

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M Pazzagli et al.
European journal of pharmacology, 383(3), 249-257 (1999-12-14)
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Trazodone is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). The drug is approved and marketed in several countries worldwide for the treatment of major depressive disorder (MDD) in adult patients. In
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