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文件

T4376

Sigma-Aldrich

N-对-甲苯磺酰基-L-苯基乙基氯甲基酮

≥97% (TLC), powder

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别名:
(S)-1-氯-3-甲苯磺酰氨基-4-苯基-2-丁酮, (S)-1-氯-4-苯基-3-甲苯磺酰氨基-2-丁酮, TPCK, 甲苯磺酰基-L-氨基联苯氯甲基酮
经验公式（希尔记法）:
C17H18ClNO3S
CAS号:
402-71-1
分子量:
351.85
Beilstein:
2895215
EC 号:
206-954-6
MDL编号:
MFCD00000935
UNSPSC代码:
12352202
PubChem化学物质编号:
24278737
NACRES:
NA.77

生物来源

synthetic

质量水平

200

检测方案

≥97% (TLC)

形式

powder

效能

10-100 μM effective concentration

颜色

white

mp

106-108 °C (lit.)

溶解性

DMSO: >10 mg/mL (stable for several months at 4°C.)
ethanol: 20 mg/mL (stable for several months at 4°C. Stock solutions (10 mM in methanol or ethanol) are stable for several months at 4°C.)

储存温度

−20°C

SMILES字符串

Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)CCl

InChI

1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1

InChI key

MQUQNUAYKLCRME-INIZCTEOSA-N

基因信息

human ... NFKB1(4790) , NKAP(79576) , NKRF(55922) , NOS2(4843) , PTGS2(5743)

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相关类别

应用

使用N-p-甲苯磺酰基-L-苯丙氨酰甲基氯酮：
  • 研究转录因子NFκB是否参与肾胺酶抗体的表达
  • 检测NF-κB激活的作用
  • 研究其对胰凝乳蛋白酶的抑制作用

某些丝氨酸蛋白酶的不可逆抑制剂；用于抑制胰蛋白酶制剂中的胰凝乳蛋白酶。

生化/生理作用

N-p-甲苯磺酰基-L-苯丙氨酰甲基氯酮(TPCK)可阻断脂多糖(LPS)或核因子κB (NFκB)的细胞因子诱导的激活，进而阻断诱生型一氧化氮合酶(iNOS)和环氧化酶-2(COX-2)转录的诱导。阻断所有有丝分裂原对pp70s6k的激活。通过抑制半胱天冬酶在某些细胞系和某些刺激剂中的作用，阻断凋亡细胞系。还会阻断紫杉醇中引起的细胞凋亡（MCF-7人乳腺癌细胞中）。 ′TPCK识别胰凝乳蛋白酶中的苯丙氨酸残基并阻止其功能。
阻断LPS或细胞因子诱导的核因子κB (NFκB)激活，其反过来阻断iNOS和COX-2转录的诱导。阻断所有有丝分裂原激活 pp70s6k。通过抑制某些细胞的半胱天冬酶加工和某些刺激，进而阻断凋亡细胞。还能够阻断由紫杉醇（在MCF-7人乳腺癌细胞中）引发的细胞凋亡。

包装

无底玻璃瓶。内容物在插入式融锥内。

注意

在-20°C下干燥保存时，保质期至少为两年。

象形图

CorrosionExclamation mark
GHS05,GHS07

警示用语：

Danger

危险声明

H315,H318,H335

危险分类

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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