T4376

N-对-甲苯磺酰基-L-苯基乙基氯甲基酮

Name: N-<I>对</I>-甲苯磺酰基-<SC>L</SC>-苯基乙基氯甲基酮
Brand: SIGMA

powder, ≥97% (TLC)

别名:

(S)-1-氯-3-甲苯磺酰氨基-4-苯基-2-丁酮, (S)-1-氯-4-苯基-3-甲苯磺酰氨基-2-丁酮, TPCK, 甲苯磺酰基-L-氨基联苯氯甲基酮

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₈ClNO₃S

化学文摘社编号:

402-71-1

分子量:

351.85

NACRES:

NA.77

PubChem Substance ID:

24278737

UNSPSC Code:

12352202

EC Number:

206-954-6

MDL number:

MFCD00000935

Beilstein/REAXYS Number:

2895215

主要文件

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产品名称

N-对-甲苯磺酰基-L-苯基乙基氯甲基酮, ≥97% (TLC), powder

InChI key

MQUQNUAYKLCRME-INIZCTEOSA-N

InChI

1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1

SMILES string

Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)CCl

biological source

synthetic

assay

≥97% (TLC)

form

powder

potency

10-100 μM effective concentration

color

white

mp

106-108 °C (lit.)

solubility

DMSO: >10 mg/mL (stable for several months at 4°C.)
ethanol: 20 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... NFKB1(4790), NKAP(79576), NKRF(55922), NOS2(4843), PTGS2(5743)

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Application

使用N-p-甲苯磺酰基-L-苯丙氨酰甲基氯酮：

研究转录因子NFκB是否参与肾胺酶抗体的表达
检测NF-κB激活的作用
研究其对胰凝乳蛋白酶的抑制作用

某些丝氨酸蛋白酶的不可逆抑制剂；用于抑制胰蛋白酶制剂中的胰凝乳蛋白酶。

Biochem/physiol Actions

N-p-甲苯磺酰基-L-苯丙氨酰甲基氯酮(TPCK)可阻断脂多糖(LPS)或核因子κB (NFκB)的细胞因子诱导的激活，进而阻断诱生型一氧化氮合酶(iNOS)和环氧化酶-2(COX-2)转录的诱导。阻断所有有丝分裂原对pp70s6k的激活。通过抑制半胱天冬酶在某些细胞系和某些刺激剂中的作用，阻断凋亡细胞系。还会阻断紫杉醇中引起的细胞凋亡（MCF-7人乳腺癌细胞中）。 ′TPCK识别胰凝乳蛋白酶中的苯丙氨酸残基并阻止其功能。

阻断LPS或细胞因子诱导的核因子κB (NFκB)激活，其反过来阻断iNOS和COX-2转录的诱导。阻断所有有丝分裂原激活 pp70^s6k。通过抑制某些细胞的半胱天冬酶加工和某些刺激，进而阻断凋亡细胞。还能够阻断由紫杉醇（在MCF-7人乳腺癌细胞中）引发的细胞凋亡。

Disclaimer

在-20°C下干燥保存时，保质期至少为两年。

General description

4°C可稳定储存数月。储备液（10 mM的甲醇或乙醇溶液）在4°C可稳定储存数月。

Packaging

无底玻璃瓶。内容物在插入式融锥内。

pictograms

GHS05,GHS07

signalword

Danger

hcodes

H315,H318,H335

pcodes

P280 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells.

Y Huang et al.

Oncogene, 18(23), 3431-3439 (1999-06-22)

The mechanism of Taxol-induced apoptosis was investigated in MCF-7 human breast carcinoma cells. Taxol-induced apoptosis was associated with phosphorylation of both c-Raf-1 and Bcl-2 and activation of ERK and JNK MAP kinases. The serine protease inhibitor N-tosyl-L-phenylalanine chloromethyl ketone (TPCK)

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Christopher S Anderson et al.

Scientific reports, 7(1), 14614-14614 (2017-11-04)

The induction of antibodies specific for the influenza HA protein stalk domain is being pursued as a universal strategy against influenza virus infections. However, little work has been done looking at natural or induced antigenic variability in this domain and

c-myc is required for osteoclast differentiation

Battaglin R, et al.

Journal of Bone and Mineral Research, 17(5), 763-773 (2002)

Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducks.

David Scheibner et al.

Scientific reports, 9(1), 11556-11556 (2019-08-11)

Avian influenza viruses (AIV) are classified into 16 hemagglutinin (HA; H1-H16) and 9 neuraminidase (NA; N1-N9) subtypes. All AIV are low pathogenic (LP) in birds, but subtypes H5 and H7 AIV can evolve into highly pathogenic (HP) forms. In the

Simultaneous quantification of total antibody and antibody-conjugated drug for XMT-1522 in human plasma using immunocapture-liquid chromatography/mass spectrometry.

Ling Xu et al.

Journal of pharmaceutical and biomedical analysis, 174, 441-449 (2019-06-21)

XMT-1522, an antibody-drug conjugate (ADC) currently in Phase I clinical development, represents the first Dolaflexin®-based, cleavable ADC with a high drug-antibody ratio (DAR). In this work, a novel immunocapture LC-MS/MS method was successfully developed for the simultaneous quantification of both

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N-对-甲苯磺酰基-L-苯基乙基氯甲基酮

powder, ≥97% (TLC)

选择尺寸

关于此项目

主要文件

属性

产品名称

InChI key

InChI

SMILES string

biological source

assay

form

potency

color

mp

solubility

storage temp.

Quality Level

Gene Information

说明

Application

Biochem/physiol Actions

Disclaimer

General description

Packaging

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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