T4376
N-对-甲苯磺酰基-L-苯基乙基氯甲基酮
powder, ≥97% (TLC)
别名:
(S)-1-氯-3-甲苯磺酰氨基-4-苯基-2-丁酮, (S)-1-氯-4-苯基-3-甲苯磺酰氨基-2-丁酮, TPCK, 甲苯磺酰基-L-氨基联苯氯甲基酮
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250 MG
CN¥2,452.68
CN¥2,452.68
预计发货时间April 27, 2025详情
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250 MG
CN¥2,452.68
About This Item
经验公式（希尔记法）:
C17H18ClNO3S
CAS号:
分子量:
351.85
Beilstein:
2895215
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
CN¥2,452.68
预计发货时间April 27, 2025详情
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此商品 | G9002 | G8877 | G3776 |
|---|---|---|---|
| assay >90% (HPLC) | assay ≥93% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) |
| form crystals | form powder | form powder | form liquid |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| manufacturer/tradename Roche | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename - |
| mol wt Mr 523.2 (GTP), Mr 567.1 (GTP-Na2) | mol wt - | mol wt - | mol wt - |
| storage condition avoid repeated freeze/thaw cycles | storage condition - | storage condition - | storage condition - |
一般描述
4°C可稳定储存数月。储备液（10 mM的甲醇或乙醇溶液）在4°C可稳定储存数月。
应用
某些丝氨酸蛋白酶的不可逆抑制剂；用于抑制胰蛋白酶制剂中的胰凝乳蛋白酶。
生化/生理作用
N-p-甲苯磺酰基-L-苯丙氨酰甲基氯酮(TPCK)可阻断脂多糖(LPS)或核因子κB (NFκB)的细胞因子诱导的激活，进而阻断诱生型一氧化氮合酶(iNOS)和环氧化酶-2(COX-2)转录的诱导。阻断所有有丝分裂原对pp70s6k的激活。通过抑制半胱天冬酶在某些细胞系和某些刺激剂中的作用，阻断凋亡细胞系。还会阻断紫杉醇中引起的细胞凋亡（MCF-7人乳腺癌细胞中）。 ′TPCK识别胰凝乳蛋白酶中的苯丙氨酸残基并阻止其功能。[3]
阻断LPS或细胞因子诱导的核因子κB (NFκB)激活，其反过来阻断iNOS和COX-2转录的诱导。阻断所有有丝分裂原激活 pp70s6k。通过抑制某些细胞的半胱天冬酶加工和某些刺激，进而阻断凋亡细胞。还能够阻断由紫杉醇（在MCF-7人乳腺癌细胞中）引发的细胞凋亡。[4]
包装
无底玻璃瓶。内容物在插入式融锥内。
注意
在-20°C下干燥保存时，保质期至少为两年。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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XMT-1522, an antibody-drug conjugate (ADC) currently in Phase I clinical development, represents the first Dolaflexin®-based, cleavable ADC with a high drug-antibody ratio (DAR). In this work, a novel immunocapture LC-MS/MS method was successfully developed for the simultaneous quantification of both
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