T4143
氨苯蝶啶
≥99%
别名:
2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine
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关于此项目
经验公式（希尔记法）:
C12H11N7
化学文摘社编号:
分子量:
253.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-904-3
MDL number:
InChI key
FNYLWPVRPXGIIP-UHFFFAOYSA-N
InChI
1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
SMILES string
Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
assay
≥99%
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL, DMSO: soluble 5.4 mg/mL, H2O: insoluble
originator
Wellspring
Quality Level
Gene Information
human ... SCNN1A(6337), SCNN1B(6338), SCNN1G(6340)
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Application
Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.
Biochem/physiol Actions
Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
Features and Benefits
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
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Khadijeh Mohammadpour et al.
Talanta, 81(4-5), 1821-1825 (2010-05-06)
In present paper, continuous wavelet transform as well as first and second derivative spectrophotometry methods are proposed for simultaneous quantitative analysis of triamterene and hydrochlorothiazide without the time-consuming extraction step. In the wavelet transform method, different wavelet families were tested
Sarah N Stabler et al.
The Cochrane database of systematic reviews, 8(8), CD007653-CD007653 (2012-08-17)
Garlic is widely used by patients for its blood pressure lowering effects. A meta-analysis published in 2008 concluded that garlic consumption lowers blood pressure in hypertensive and normotensive patients. Therefore, it is important to review the currently available evidence to
Mehrdad Hamidi et al.
Regulatory toxicology and pharmacology : RTP, 59(1), 149-156 (2011-01-05)
In this study, an open, double-blind, randomized, two-period, two-group crossover design was conducted in 14 healthy volunteers to study the bioequivalence of a fixed-dose generic product. After administration of test or reference products to each volunteer, both active ingredients were
A Kato et al.
The American journal of physiology, 276(1 Pt 2), F62-F71 (1999-01-14)
Infusing urea into low-protein-fed mammals increases urine concentration within 5-10 min. To determine which urea transporter may be responsible, we measured urea transport in perfused IMCD3 segments [inner medullary collecting duct (IMCD) segments from the deepest third of the IMCD]
Ki-Woong Jeong et al.
Biochemistry, 50(22), 4843-4854 (2011-05-07)
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