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Merck
CN

T4069

Sigma-Aldrich

JC-1

≥97% purity, solid

别名:

5,5',6,6′-四氯-1,1′,3,3′-四乙基-脒酞菁碘化物, 5,5',6,6′-四氯-1,1′,3,3′-四乙基苯并咪唑碳氰碘化物, CBIC2(3)

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About This Item

经验公式(希尔记法):
C25H27Cl4IN4
CAS号:
分子量:
652.23
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47

product name

JC-1, solid

检测方案

≥97%

质量水平

形式

solid

颜色

red

ε (消光系数)

≥175000 at 511-517 nm in methanol

应用

diagnostic assay manufacturing
hematology
histology

储存温度

room temp

SMILES字符串

[I-].CCN1C(=C\C=C\c2n(CC)c3cc(Cl)c(Cl)cc3[n+]2CC)/N(CC)c4cc(Cl)c(Cl)cc14

InChI

1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1

InChI key

FYNNIUVBDKICAX-UHFFFAOYSA-M

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应用

花青染料 Jc-1已被用于确定线粒体跨膜电位。
双发射电位敏感探针,可用于测量线粒体膜电位。 在低膜电位时,JC-1是一个绿色荧光(λex 520nm)单体。在较高的电位下,JC-1形成带有红色荧光(λem 596nm)的“J-聚集体”,其表现出宽的激发和非常窄的发射光谱。JC-1的红色与绿色荧光的比率仅取决于膜电位,并且不受线粒体大小、形状或密度的影响。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Xianbin Cao et al.
Cellular signalling, 62, 109337-109337 (2019-06-08)
Radiation-induced tumor cells death is the theoretical basis of tumor radiotherapy. Death signaling disorder is the most important factor for radioresistance. However, the signaling pathway(s) leading to radiation-triggered cell death is (are) still not completely known. To better understand the
Sulfated polysaccharide-protein complex sensitizes doxorubicin-induced apoptosis of breast cancer cells in vitro and in vivo
Jie Wang
Experimental and Therapeutic Medicine (2016)
JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry
A Perelman
Cell Death & Disease (2012)
Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
Chunyan Xue
Oncology Letters (2016)
Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion
Li L
Cell Death & Disease (2016)

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