所有图片(1)
别名:
2-氰基-3-（3,4-二羟基苯基）-N-（苄基）-2-丙烯酰胺, 2-氰基-3-（3,4-二羟基苯基）-N-（苯甲基）-2-丙烯酰胺
经验公式（希尔记法）:
C17H14N2O3
推荐产品
生物来源
synthetic (organic)
质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
yellow
溶解性
DMSO: soluble 10 mg/ml, clear, yellow
ethanol: 5 mg/mL
H2O: insoluble
储存温度
−20°C
SMILES字符串
Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc2ccccc2
InChI
1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChI key
TUCIOBMMDDOEMM-RIYZIHGNSA-N
基因信息
human ... EGFR(1956) , ERBB2(2064) , IL2(3558) , JAK2(3717)
应用
Tyrphostin AG 已被用于阻断 IL-6 细胞因子信号传导，研究其对神经胶质细胞反应性的影响 5 。AG 490 也被用作人脐静脉内皮细胞的 JAK2 抑制剂 6 。
生化/生理作用
Jak-2 蛋白酪氨酸激酶 (PTK) 抑制剂。抑制白细胞介素 2 (IL-2) 驱动的有丝分裂并触发 Sezary 综合征（一种皮肤 T 细胞淋巴瘤的白血病变体）的肿瘤细胞凋亡。
特点和优势
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
注意
光敏
制备说明
Tyrphostin AG 490 溶于乙醇，浓度为 5 mg/mL，不溶于水。也可溶于 10 mg/mL 的 DMSO 中，并产生澄清的黄色溶液。
WGK
WGK 3
J Abe et al.
The Journal of biological chemistry, 274(30), 21003-21010 (1999-07-20)
Reactive oxygen species (ROS) activate Ras and the extracellular signal-regulated kinase (ERK) cascade. Because JAK2 is a critical mediator for Ras/Raf/ERK activation by several hormones, we examined the role of JAK2 in ROS signal events. H(2)O(2) stimulated JAK2 activity in
Mengqi Jiang et al.
Oxidative medicine and cellular longevity, 2021, 7385160-7385160 (2021-08-31)
Obesity is considered as a risk factor of osteoarthritis (OA), but the precise relationship is still poorly understood. Leptin, one of the most relevant factors secreted by adipose tissues, plays an important role in the pathogenesis of OA. Our aim
Pei-Ju Sung et al.
Cancer research, 79(14), 3651-3661 (2019-05-16)
Netrin-1 is upregulated in a large fraction of human neoplasms. In multiple animal models, interference with netrin-1 is associated with inhibition of tumor growth and metastasis. Although netrin-1 upregulation was initially described in cancer cells, we report here that in
K W Eriksen et al.
Leukemia, 15(5), 787-793 (2001-05-23)
Interleukin-2 (IL-2) is a growth factor which upon binding to high-affinity receptors (IL-2Ralphabetagamma) triggers mitogenesis in T cells. IL-2Ralpha expression is restricted to T cells which have recently encountered antigen, and in healthy individuals the majority (>95%) of peripheral T
Tao Geng et al.
Gene, 595(1), 69-76 (2016-10-04)
Innate immunity was critical in insects defensive system and able to be induced by Janus kinase/signal transducer and activator of transcription cascade transduction (JAK/STAT) signaling pathway. Currently, it had been identified many JAK/STAT signaling pathway-related genes in silkworm, but little
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