T3146
三甲丙咪嗪标准液 马来酸盐
≥98% (TLC), serotonin transport blocker, powder
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经验公式（希尔记法）:
C20H26N2 · C4H4O4
化学文摘社编号:
分子量:
410.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
208-318-3
MDL number:
产品名称
三甲丙咪嗪标准液 马来酸盐, ≥98% (TLC), powder
InChI key
YDGHCKHAXOUQOS-WLHGVMLRSA-N
InChI
1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22;5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES string
OC(=O)\C=C\C(O)=O.CC(CN(C)C)CN1c2ccccc2CCc3ccccc13
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow
originator
Sanofi Aventis
storage temp.
2-8°C
Quality Level
Gene Information
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Application
Trimipramine maleate has been used to develop chiral separation methods using capillary electrophoresis4.
Biochem/physiol Actions
Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake.
Preparation Note
Trimipramine maleate is soluble in chloroform at 50 mg/ml to yield a clear, colorless to faint yellow solution.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
J M Langosch et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(3), 209-212 (1998-08-26)
Trimipramine has been classified as an atypical tricyclic antidepressant, because only weak inhibitory effects on serotonin and/or noradrenaline reuptake have been found. Since some antidepressive drugs (e.g. imipramine) and other agents used in the treatment of affective disorders (e.g. carbamazepine)
Chiral separation in non-aqueous media by capillary electrophoresis using the ion-pair principle.
Bjornsdottir, I., et al.
Journal of Chromatography A, 745(1), 37-44 (1996)
G Chouinard et al.
Cellular and molecular neurobiology, 19(4), 533-552 (1999-06-24)
1. The benzodiazepines are among the most frequently prescribed of all drugs and have been used for their anxiolytic, anticonvulsant, and sedative/hypnotic properties. Since absorption rates, volumes of distribution, and elimination rates differ greatly among the benzodiazepine derivatives, each benzodiazepine
F Plenge-Tellechea et al.
Archives of biochemistry and biophysics, 370(1), 119-125 (1999-09-25)
Tricyclic antidepressants are moderately potent inhibitors of the plasma membrane Ca(2+)-ATPase activity measured in erythrocyte ghosts. For the calmodulin-activated activity, half-maximal inhibition was observed in the presence of 0.25 mM clomipramine. Desipramine, imipramine, and trimipramine show half-maximal inhibition in the
Ali R Fakhari et al.
Electrophoresis, 33(3), 506-515 (2012-01-31)
A sensitive, simple and reproducible method was developed for preconcentration and determination of trimipramine (TPM) enantiomers in biological samples using electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis (CE). During the extraction, TPM enantiomers migrated from a 5 mL sample solution through
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