推荐产品
生物来源
synthetic (organic)
质量水平
无菌性
non-sterile
检测方案
≥95% (HPLC)
形式
powder
旋光性
[α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
技术
transfection: suitable
mp
234-238 °C (lit.)
溶解性
4 M NH4OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
运输
ambient
储存温度
−20°C
SMILES字符串
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
InChI
1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChI key
AUYYCJSJGJYCDS-LBPRGKRZSA-N
基因信息
human ... THRA(7067) , THRB(7068)
rat ... Thra(81812) , Thrb(24831)
正在寻找类似产品? 访问 产品对比指南
相关类别
应用
3,3′5-三碘-L-甲状腺原氨酸可用于胰岛素样生长因子I的检测，采用双抗体放射免疫分析法。该产品还可用于293T细胞的 体外 转染。
生化/生理作用
3,3′5-三碘-L-甲状腺原氨酸也称为O-(4-羟基-3-碘苯)-3,5-二碘-L-酪氨酸或T3，是具有生物活性的甲状腺激素。在甲状腺功能减退症中，三碘腺苷能增强情绪和神经心理功能。本品对肝脏FGF21表达也有正向调节作用并通过提高许多代谢酶（如用于氧化磷酸化的己糖激酶、肝脏葡萄糖6-磷酸酶以及线粒体酶）的水平，促进葡萄糖、脂肪和蛋白质的代谢分解。此外，该产品可促进儿童正常身体生长，并对胎儿中枢神经系统的成熟至关重要。
制备说明
3,3′5-三碘-L-甲状腺原氨酸以5 mg/ml溶于4M NH4OH的MeOH中，生成无色至淡黄色，澄清至略模糊的溶液。
其他说明
This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877
警示用语：
Danger
危险声明
危险分类
STOT RE 1
靶器官
Thyroid,Cardio-vascular system,Kidney
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
W A Head et al.
Journal of animal science, 74(9), 2152-2157 (1996-09-01)
Targhee ewes (n = 22, average age 5 yr) rearing twin lambs were used to investigate serum growth hormone (GH), IGF-I, triiodothyronine (T3), thyroxine (T4), and prolactin (PRL; ewes only) concentrations associated with selection pressure for lifetime production of kilograms
Soledad Bárez-López et al.
PloS one, 14(12), e0226017-e0226017 (2019-12-07)
Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers.
Andrew C Adams et al.
The Journal of biological chemistry, 285(19), 14078-14082 (2010-03-20)
Thyroid hormone has profound and diverse effects on liver metabolism. Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21). Mice treated with T3 showed a
R Bunevicius et al.
The New England journal of medicine, 340(6), 424-429 (1999-02-11)
Patients with hypothyroidism are usually treated with thyroxine (levothyroxine) only, although both thyroxine and triiodothyronine are secreted by the normal thyroid gland. Whether thyroid secretion of triiodothyronine is physiologically important is unknown. We compared the effects of thyroxine alone with
Takahiro Nojiri et al.
Endocrine journal, 66(5), 409-422 (2019-03-01)
Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门