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Merck
CN

T2376

Sigma-Aldrich

L-甲状腺素

≥98% (HPLC)

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别名:
3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T4
线性分子式:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
CAS号:
分子量:
776.87
Beilstein:
2228515
EC 号:
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.32

生物来源

synthetic

质量水平

无菌性

non-sterile

检测方案

≥98% (HPLC)

形式

powder

技术

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

溶解性

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, yellow

运输

ambient

储存温度

room temp

SMILES字符串

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

基因信息

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相关类别

应用

L-甲状腺素用于研究光诱导的 T4 到 T3 的激素转化在对日本鹌鹑性腺的光周期反应的调节作用。该产品用作测试化合物,用于研究多种激素对培养的大鼠睾丸细胞表面形态的影响。

生化/生理作用

甲状腺素是一种含碘激素,由甲状腺滤泡细胞中的甲状腺球蛋白产生。L-甲状腺素可降低亚临床甲状腺功能减退症患者的总胆固醇水平、低密度脂蛋白胆固醇以及腰臀比。因此,有助于改善心血管危险因素以及能增强疲劳症状。
L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素,由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用,进而影响蛋白质的合成。

包装

无底玻璃瓶。内含物装在插入的融合锥内。

制备说明

L-甲状腺素溶于 4M 甲醇的氢氧化铵溶液中,浓度为 50 mg/ml,得到澄清至浑浊的黄色至暗黄色溶液。

相关产品

产品编号
说明
价格

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

STOT RE 1

靶器官

Thyroid,Cardio-vascular system,Kidney

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

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